Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman

Postmenopausal women and people over the age of 70 are more likely to develop osteoporosis. It is recognized as significant comorbidity among those with type 2 diabetes mellitus (T2DM), and male fractures are on the rise with higher rates of mortality than women (37.5% vs 28.2% respectively). Howeve...

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Main Author:	Kamaruzaman, Hanis Rabeah
Format:	Thesis
Language:	English
Published:	2022
Subjects:	Diabetes Mellitus
Online Access:	https://ir.uitm.edu.my/id/eprint/94036/2/94036.pdf
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spelling	my-uitm-ir.940362024-08-21T04:03:23Z Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman 2022 Kamaruzaman, Hanis Rabeah Diabetes Mellitus Postmenopausal women and people over the age of 70 are more likely to develop osteoporosis. It is recognized as significant comorbidity among those with type 2 diabetes mellitus (T2DM), and male fractures are on the rise with higher rates of mortality than women (37.5% vs 28.2% respectively). However, there is a scarcity of data linking T2DM and metabolic bone disease in men. OBJECTIVE Our study aimed to determine the prevalence of metabolic bone diseases, including osteoporosis and osteopenia, and the associated factors, bone turnover markers, and vitamin D in male with T2DM. METHOD This is a cross-sectional, single-centre study in men above 50 years of age with T2DM, conducted from December 2021 to June 2022. Demographic data, baseline comorbidities, and biochemical profiles including urine albumin-creatinine ratio (UACR) were obtained. Bone turnover markers including C-terminal telopeptide of type I collagen (CTX) and bone-specific alkaline phosphates (bsALP) were measured. Osteoporosis and osteopenia were determined by Dual Energy X- ray Absorptiometry (DEXA). RESULT 148 male with T2DM with a median age of 64 (IqR 11) years was recruited. The prevalence of metabolic bone disease in the study population was 20.3%. Multivariate analysis shows total bilirubin level [OR: 1.13 (95% CI: 1.050, 1.223) p<0.001], high intact parathyroid hormone (iPTH) level ≥6.9 pmol/L [OR 3.05 (95% CI: 1.141, 8.187), p=0.026] and use of dipeptidyl peptidase-4 inhibitor (DPP4i) [OR 0.274 (95% CI: 0.093, 0.809) p=0.01] are predictors of metabolic bone disease in the study population. CONCLUSION Metabolic bone disease affects about 1 in 5 men with T2DM patients, This study underscores the importance of screening for metabolic bone disease in men T2DM with high total bilirubin and high iPTH level to allow early detection, initiation of treatment and other preventive measures. There is need for further study looking at association of DPP4i with metabolic bone disease Faculty of Medicine 2022 Thesis https://ir.uitm.edu.my/id/eprint/94036/ https://ir.uitm.edu.my/id/eprint/94036/2/94036.pdf text en public masters Universiti Teknologi MARA Faculty of Medicine
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Diabetes Mellitus
spellingShingle	Diabetes Mellitus Kamaruzaman, Hanis Rabeah Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman
description	Postmenopausal women and people over the age of 70 are more likely to develop osteoporosis. It is recognized as significant comorbidity among those with type 2 diabetes mellitus (T2DM), and male fractures are on the rise with higher rates of mortality than women (37.5% vs 28.2% respectively). However, there is a scarcity of data linking T2DM and metabolic bone disease in men. OBJECTIVE Our study aimed to determine the prevalence of metabolic bone diseases, including osteoporosis and osteopenia, and the associated factors, bone turnover markers, and vitamin D in male with T2DM. METHOD This is a cross-sectional, single-centre study in men above 50 years of age with T2DM, conducted from December 2021 to June 2022. Demographic data, baseline comorbidities, and biochemical profiles including urine albumin-creatinine ratio (UACR) were obtained. Bone turnover markers including C-terminal telopeptide of type I collagen (CTX) and bone-specific alkaline phosphates (bsALP) were measured. Osteoporosis and osteopenia were determined by Dual Energy X- ray Absorptiometry (DEXA). RESULT 148 male with T2DM with a median age of 64 (IqR 11) years was recruited. The prevalence of metabolic bone disease in the study population was 20.3%. Multivariate analysis shows total bilirubin level [OR: 1.13 (95% CI: 1.050, 1.223) p<0.001], high intact parathyroid hormone (iPTH) level ≥6.9 pmol/L [OR 3.05 (95% CI: 1.141, 8.187), p=0.026] and use of dipeptidyl peptidase-4 inhibitor (DPP4i) [OR 0.274 (95% CI: 0.093, 0.809) p=0.01] are predictors of metabolic bone disease in the study population. CONCLUSION Metabolic bone disease affects about 1 in 5 men with T2DM patients, This study underscores the importance of screening for metabolic bone disease in men T2DM with high total bilirubin and high iPTH level to allow early detection, initiation of treatment and other preventive measures. There is need for further study looking at association of DPP4i with metabolic bone disease
format	Thesis
qualification_level	Master's degree
author	Kamaruzaman, Hanis Rabeah
author_facet	Kamaruzaman, Hanis Rabeah
author_sort	Kamaruzaman, Hanis Rabeah
title	Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman
title_short	Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman
title_full	Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman
title_fullStr	Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman
title_full_unstemmed	Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman
title_sort	prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / hanis rabeah kamaruzaman
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Medicine
publishDate	2022
url	https://ir.uitm.edu.my/id/eprint/94036/2/94036.pdf
_version_	1811768783995404288

Prevalence and associated factors of metabolic bone disease in male with type 2 diabetes mellitus / Hanis Rabeah Kamaruzaman

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