Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly

Background/Objective: Cosmetic contact dermatitis (CD) has been an increasing concern as many new products are introduced. The face is the most exposed to cosmetics which results in face dermatitis. We aimed to determine the prevalence of positive reactions to cosmetic allergens from standard and co...

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Main Author:	Raja Zulkifly, Raja Noor Azimah
Format:	Thesis
Language:	English
Published:	2023
Subjects:	Dermatitis Dermatotoxicology
Online Access:	https://ir.uitm.edu.my/id/eprint/95277/1/95277.PDF
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id	my-uitm-ir.95277
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spelling	my-uitm-ir.952772024-08-26T03:40:04Z Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly 2023 Raja Zulkifly, Raja Noor Azimah Dermatitis Diseases associated with hypersensitivity. Allergic diseases of the skin Dermatotoxicology Background/Objective: Cosmetic contact dermatitis (CD) has been an increasing concern as many new products are introduced. The face is the most exposed to cosmetics which results in face dermatitis. We aimed to determine the prevalence of positive reactions to cosmetic allergens from standard and cosmetic patch test series among suspected face allergic contact dermatitis to cosmetic patients who attended HUiTM Dermatology Clinic. Methods: A cross-sectional study was performed between June to December 2022 involving 49 patients aged between 18-30 years old. All patients underwent standard and cosmetic series patch testing. The results were according to the International Contact Dermatitis Research Group (ICDRG) protocol. Results: Our study cohort compressed 93.8% patch test positivity rate either to standard, cosmetic or both series. There was a high prevalence (n=49, 85.4%) of positivity to cosmetic series alone. The most prevalent clinical presentation among suspected face CD was erythema (n=49, 25.2%) which cheek being the most frequently affected site (n=45, 40.5%). Facial and hair care products (n=45, 22.6% and 20.1 %) respectively were the most suspected product causing allergic CD. Cosmetic patch test positivity was highest with preservative allergens (68%) predominantly to thimerosal (n=41, 8.1 %) followed by sodium metabisulfite (n=4 l, 4.5%). Antioxidant allergens that probable cause CD were gallate mix (n=4 l, 7.2%) and dodecyl gallate (n=41, 5.4%). The most positive standard allergens were nickel(l l) sulfate hexahydrate (n=32, 15.1 %), textile dye mix (n=32, 15.1 %), caine mix III and fragrance mix (n=32, 6.32%) respectively. Conclusion: The most cosmetic related allergens identified were from preservative (68%), fragrance (45%), emulsifier (11 %) and antioxidant (7%) groups. National multicentre registry data is required to support national cosmetic product legislation and to enhance public education. Faculty of Medicine 2023 Thesis https://ir.uitm.edu.my/id/eprint/95277/ https://ir.uitm.edu.my/id/eprint/95277/1/95277.PDF text en public masters Universiti Teknologi MARA Dermatology Unit Taib, Tarita Ab Wahab, Sabrina
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Taib, Tarita Ab Wahab, Sabrina
topic	Dermatitis Dermatitis Dermatotoxicology
spellingShingle	Dermatitis Dermatitis Dermatotoxicology Raja Zulkifly, Raja Noor Azimah Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly
description	Background/Objective: Cosmetic contact dermatitis (CD) has been an increasing concern as many new products are introduced. The face is the most exposed to cosmetics which results in face dermatitis. We aimed to determine the prevalence of positive reactions to cosmetic allergens from standard and cosmetic patch test series among suspected face allergic contact dermatitis to cosmetic patients who attended HUiTM Dermatology Clinic. Methods: A cross-sectional study was performed between June to December 2022 involving 49 patients aged between 18-30 years old. All patients underwent standard and cosmetic series patch testing. The results were according to the International Contact Dermatitis Research Group (ICDRG) protocol. Results: Our study cohort compressed 93.8% patch test positivity rate either to standard, cosmetic or both series. There was a high prevalence (n=49, 85.4%) of positivity to cosmetic series alone. The most prevalent clinical presentation among suspected face CD was erythema (n=49, 25.2%) which cheek being the most frequently affected site (n=45, 40.5%). Facial and hair care products (n=45, 22.6% and 20.1 %) respectively were the most suspected product causing allergic CD. Cosmetic patch test positivity was highest with preservative allergens (68%) predominantly to thimerosal (n=41, 8.1 %) followed by sodium metabisulfite (n=4 l, 4.5%). Antioxidant allergens that probable cause CD were gallate mix (n=4 l, 7.2%) and dodecyl gallate (n=41, 5.4%). The most positive standard allergens were nickel(l l) sulfate hexahydrate (n=32, 15.1 %), textile dye mix (n=32, 15.1 %), caine mix III and fragrance mix (n=32, 6.32%) respectively. Conclusion: The most cosmetic related allergens identified were from preservative (68%), fragrance (45%), emulsifier (11 %) and antioxidant (7%) groups. National multicentre registry data is required to support national cosmetic product legislation and to enhance public education.
format	Thesis
qualification_level	Master's degree
author	Raja Zulkifly, Raja Noor Azimah
author_facet	Raja Zulkifly, Raja Noor Azimah
author_sort	Raja Zulkifly, Raja Noor Azimah
title	Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly
title_short	Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly
title_full	Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly
title_fullStr	Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly
title_full_unstemmed	Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly
title_sort	patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / dr. raja noor azimah raja zulkifly
granting_institution	Universiti Teknologi MARA
granting_department	Dermatology Unit
publishDate	2023
url	https://ir.uitm.edu.my/id/eprint/95277/1/95277.PDF
_version_	1811768814138818560

Patch testing in suspected face allergic contact dermatitis to cosmetics in a tertiary hospital: a prevalence study on causative cosmetic allergens / Dr. Raja Noor Azimah Raja Zulkifly

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