Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof

Quercetin which is one of the flavonoid derivatives has several health-promoting effects on humans, including antioxidant, anticancer, antiviral, antibacterial, neuroprotective, and cardioprotective activities. The biological and pharmacological actions of metal-chelated quercetin are much greater t...

Full description

Saved in:

Bibliographic Details
Main Author:	Yusof, Muhammad Azrin
Format:	Thesis
Language:	English
Published:	2022
Subjects:	Physical and theoretical chemistry Analytical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/96259/1/96259.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.96259
record_format	uketd_dc
spelling	my-uitm-ir.962592024-05-31T09:32:53Z Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof 2022-08 Yusof, Muhammad Azrin Physical and theoretical chemistry Analytical chemistry Quercetin which is one of the flavonoid derivatives has several health-promoting effects on humans, including antioxidant, anticancer, antiviral, antibacterial, neuroprotective, and cardioprotective activities. The biological and pharmacological actions of metal-chelated quercetin are much greater than those of quercetin ligand. Recently, it was shown that flavonoids such as quercetin form high-affinity compounds with transition metal ions such as iron and nickel. This technique is regarded as the primary means of enhancing their efficiency in biological tasks such as radical scavenging. In this study, Fe(II) and Ni(II) complexes with quercetin ligand were synthesized in a ratio of quercetin 2:1 metal and characterized using spectroscopic methods such as UV-Vis and FTIR. Fe(II)-quercetin complex was formed with a dark black colour, whereas Ni(II)-quercetin complex was dark brown. According to UV-Vis spectral data, the band I (cinnamoyl system) of both Fe(II)-quercetin and Ni(II)- quercetin complexes had undergone a bathochromic shift, shifting towards longer wavelengths (lower energy). For FTIR spectroscopy, the v(C=O), v(C=C), v(C-OH), and v(O-H) frequencies in Fe(II)-quercetin and Ni(II)-quercetin complexes were shifted somewhat lower from their original value, but v(C-O-C) shifted slightly higher. Additional spectrum data for Fe(II)-quercetin and Ni(II)-quercetin were discovered at 519 cm−1 and 473 cm−1, respectively, representing the v(M-O) absorbance. Both spectroscopic studies demonstrated the complexation of metal with quercetin through an oxygen atom of hydroxyl and carbonyl groups. 2022-08 Thesis https://ir.uitm.edu.my/id/eprint/96259/ https://ir.uitm.edu.my/id/eprint/96259/1/96259.pdf text en public Universiti Teknologi MARA, Sarawak Faculty of Applied Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Physical and theoretical chemistry Analytical chemistry
spellingShingle	Physical and theoretical chemistry Analytical chemistry Yusof, Muhammad Azrin Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof
description	Quercetin which is one of the flavonoid derivatives has several health-promoting effects on humans, including antioxidant, anticancer, antiviral, antibacterial, neuroprotective, and cardioprotective activities. The biological and pharmacological actions of metal-chelated quercetin are much greater than those of quercetin ligand. Recently, it was shown that flavonoids such as quercetin form high-affinity compounds with transition metal ions such as iron and nickel. This technique is regarded as the primary means of enhancing their efficiency in biological tasks such as radical scavenging. In this study, Fe(II) and Ni(II) complexes with quercetin ligand were synthesized in a ratio of quercetin 2:1 metal and characterized using spectroscopic methods such as UV-Vis and FTIR. Fe(II)-quercetin complex was formed with a dark black colour, whereas Ni(II)-quercetin complex was dark brown. According to UV-Vis spectral data, the band I (cinnamoyl system) of both Fe(II)-quercetin and Ni(II)- quercetin complexes had undergone a bathochromic shift, shifting towards longer wavelengths (lower energy). For FTIR spectroscopy, the v(C=O), v(C=C), v(C-OH), and v(O-H) frequencies in Fe(II)-quercetin and Ni(II)-quercetin complexes were shifted somewhat lower from their original value, but v(C-O-C) shifted slightly higher. Additional spectrum data for Fe(II)-quercetin and Ni(II)-quercetin were discovered at 519 cm−1 and 473 cm−1, respectively, representing the v(M-O) absorbance. Both spectroscopic studies demonstrated the complexation of metal with quercetin through an oxygen atom of hydroxyl and carbonyl groups.
format	Thesis
author	Yusof, Muhammad Azrin
author_facet	Yusof, Muhammad Azrin
author_sort	Yusof, Muhammad Azrin
title	Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof
title_short	Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof
title_full	Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof
title_fullStr	Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof
title_full_unstemmed	Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof
title_sort	synthesis and characterization of fe(ii) and ni(ii) complexes with quercetin / muhammad azrin md yusof
granting_institution	Universiti Teknologi MARA, Sarawak
granting_department	Faculty of Applied Sciences
publishDate	2022
url	https://ir.uitm.edu.my/id/eprint/96259/1/96259.pdf
_version_	1804889981262495744

Synthesis and characterization of Fe(II) and Ni(II) complexes with Quercetin / Muhammad Azrin Md Yusof

Similar Items