Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab

The World Health Organization (WHO) in 1997 recommended that effective locally available plants should be used as substitutes for drugs. Psidium guajava or guava is one of local plants found in abundance in Malaysia. The pharmacological effects, specifically on locomotor activity and central nervous...

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Main Author:	Abd Wahab, Mohd Shahezwan
Format:	Thesis
Language:	English
Published:	2005
Subjects:	RM Therapeutics Pharmacology
Online Access:	https://ir.uitm.edu.my/id/eprint/98481/1/98481.PDF
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id	my-uitm-ir.98481
record_format	uketd_dc
spelling	my-uitm-ir.984812024-08-27T18:11:34Z Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab 2005 Abd Wahab, Mohd Shahezwan RM Therapeutics. Pharmacology Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) The World Health Organization (WHO) in 1997 recommended that effective locally available plants should be used as substitutes for drugs. Psidium guajava or guava is one of local plants found in abundance in Malaysia. The pharmacological effects, specifically on locomotor activity and central nervous system by the plant should be exploited for clinical use. This study is carried out to evaluate the effects of Psidium guajava leaf extract on the locomotor activity, central nervous system and also on the intake of food and water in mice. For the evaluation of locomotor activity of the mice, the Animal Activity Monitor by Coulboum Instrument is used. The extract at doses of 1, 3 and 5 mg/kg was acutely and chronically administered through the intraperitoneal route to male adult mice (n = 5 per group) before they were subjected to the experiment. Normal saline was administered as control. The instrument is also used to investigate the effect of the Psidium guajava leaf extract on food and water intake of the mice. Forced swimming test was implemented to study the depressant effect of the mice. Depressive activity on the central nervous system was demonstrated by several alterations in the mice behaviour in the pharmacological screening. The results obtained showed that the leaf extract caused reduction of locomotor activity as well as reduction in food and water intake in mice. The extract also produces central nervous system depressant effects. Further studies should be conducted to uncover the mechanism of action and also possible therapeutic use. 2005 Thesis https://ir.uitm.edu.my/id/eprint/98481/ https://ir.uitm.edu.my/id/eprint/98481/1/98481.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Abdul Majeed, Abu Bakar
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Majeed, Abu Bakar
topic	RM Therapeutics Pharmacology RM Therapeutics Pharmacology
spellingShingle	RM Therapeutics Pharmacology RM Therapeutics Pharmacology Abd Wahab, Mohd Shahezwan Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
description	The World Health Organization (WHO) in 1997 recommended that effective locally available plants should be used as substitutes for drugs. Psidium guajava or guava is one of local plants found in abundance in Malaysia. The pharmacological effects, specifically on locomotor activity and central nervous system by the plant should be exploited for clinical use. This study is carried out to evaluate the effects of Psidium guajava leaf extract on the locomotor activity, central nervous system and also on the intake of food and water in mice. For the evaluation of locomotor activity of the mice, the Animal Activity Monitor by Coulboum Instrument is used. The extract at doses of 1, 3 and 5 mg/kg was acutely and chronically administered through the intraperitoneal route to male adult mice (n = 5 per group) before they were subjected to the experiment. Normal saline was administered as control. The instrument is also used to investigate the effect of the Psidium guajava leaf extract on food and water intake of the mice. Forced swimming test was implemented to study the depressant effect of the mice. Depressive activity on the central nervous system was demonstrated by several alterations in the mice behaviour in the pharmacological screening. The results obtained showed that the leaf extract caused reduction of locomotor activity as well as reduction in food and water intake in mice. The extract also produces central nervous system depressant effects. Further studies should be conducted to uncover the mechanism of action and also possible therapeutic use.
format	Thesis
qualification_level	Bachelor degree
author	Abd Wahab, Mohd Shahezwan
author_facet	Abd Wahab, Mohd Shahezwan
author_sort	Abd Wahab, Mohd Shahezwan
title	Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_short	Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_full	Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_fullStr	Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_full_unstemmed	Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab
title_sort	pharmacological behavioural effects of psidium guajava leaf extract / mohd shahezwan abd wahab
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2005
url	https://ir.uitm.edu.my/id/eprint/98481/1/98481.PDF
_version_	1811768925149462528

Pharmacological behavioural effects of psidium guajava leaf extract / Mohd Shahezwan Abd Wahab

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