Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin

It is recognized that poor hand washing compliance is a key factor in the spread of infections in the healthcare environment. Even with the introduction of new and improved formulations of hand washes, many have rejected its use as high frequency, repeated hand washing can damage skin thus leading t...

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Main Author:	Nordin, Muhd Nor Hazli
Format:	Thesis
Language:	English
Published:	2005
Subjects:	Antibacterial agents Organic materia medica (General)
Online Access:	https://ir.uitm.edu.my/id/eprint/98537/1/98537.PDF
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id	my-uitm-ir.98537
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spelling	my-uitm-ir.985372024-08-27T18:12:40Z Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin 2005 Nordin, Muhd Nor Hazli Antibacterial agents Organic materia medica (General) Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) It is recognized that poor hand washing compliance is a key factor in the spread of infections in the healthcare environment. Even with the introduction of new and improved formulations of hand washes, many have rejected its use as high frequency, repeated hand washing can damage skin thus leading to irritant contact dermatitis or other skin-related problems. Natural plant extracts or oil with antimicrobial property may be incorporated to produce a mild and moisturizing yet effective hand wash. In the present study, a novel oil from Sindora bruggemanii, known as sepetir, which is used among the locals for wound healing was assessed for its potential as an antimicrobial agent to be incorporated in hand washes. The secondary objective was to assess the efficacy of a commercial preparation of tea tree oil, and water- and oil-base sea cucumber (‘gamat’) preparations against E. coli (ATCC 25922), S. aureus (ATCC 6538), M. luteus (ATCC 10240), and C. albicans (ATCC 10231). The antimicrobial activity of two commercial hand washes (water-base hand wash, Dettol and alcohol-base hand wash, Aubry) were also evaluated. A revised method of agar-well diffusion technique was adapted and all compounds were tested against human pathogens. The efficacy of each compound was determined by the inhibition zone produced. Sepetir oil was able to provide a significant (P<0.05) inhibition but only limited to Gram positive bacteria. Tea tree oil exhibited a strong antibacterial and antifungal activity against all pathogens studied, yielding a significantly (P<0.01) large inhibition zone. Both the commercial preparations of sea cucumber had no inhibitory effect on any of the above-mentioned microorganisms. Water-base hand wash (Dettol) on the other hand, provided broad and significant (P<0.05) protection against these microorganisms compared to alcohol-base hand wash (Aubry). Results indicate that tea tree oil is more promising than sepetir oil to be used as a component of hand washes in future. 2005 Thesis https://ir.uitm.edu.my/id/eprint/98537/ https://ir.uitm.edu.my/id/eprint/98537/1/98537.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Antibacterial agents Organic materia medica (General) Antibacterial agents
spellingShingle	Antibacterial agents Organic materia medica (General) Antibacterial agents Nordin, Muhd Nor Hazli Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin
description	It is recognized that poor hand washing compliance is a key factor in the spread of infections in the healthcare environment. Even with the introduction of new and improved formulations of hand washes, many have rejected its use as high frequency, repeated hand washing can damage skin thus leading to irritant contact dermatitis or other skin-related problems. Natural plant extracts or oil with antimicrobial property may be incorporated to produce a mild and moisturizing yet effective hand wash. In the present study, a novel oil from Sindora bruggemanii, known as sepetir, which is used among the locals for wound healing was assessed for its potential as an antimicrobial agent to be incorporated in hand washes. The secondary objective was to assess the efficacy of a commercial preparation of tea tree oil, and water- and oil-base sea cucumber (‘gamat’) preparations against E. coli (ATCC 25922), S. aureus (ATCC 6538), M. luteus (ATCC 10240), and C. albicans (ATCC 10231). The antimicrobial activity of two commercial hand washes (water-base hand wash, Dettol and alcohol-base hand wash, Aubry) were also evaluated. A revised method of agar-well diffusion technique was adapted and all compounds were tested against human pathogens. The efficacy of each compound was determined by the inhibition zone produced. Sepetir oil was able to provide a significant (P<0.05) inhibition but only limited to Gram positive bacteria. Tea tree oil exhibited a strong antibacterial and antifungal activity against all pathogens studied, yielding a significantly (P<0.01) large inhibition zone. Both the commercial preparations of sea cucumber had no inhibitory effect on any of the above-mentioned microorganisms. Water-base hand wash (Dettol) on the other hand, provided broad and significant (P<0.05) protection against these microorganisms compared to alcohol-base hand wash (Aubry). Results indicate that tea tree oil is more promising than sepetir oil to be used as a component of hand washes in future.
format	Thesis
qualification_level	Bachelor degree
author	Nordin, Muhd Nor Hazli
author_facet	Nordin, Muhd Nor Hazli
author_sort	Nordin, Muhd Nor Hazli
title	Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin
title_short	Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin
title_full	Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin
title_fullStr	Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin
title_full_unstemmed	Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin
title_sort	antimicrobial activity of sindora bruggemanii (sepetir) oil / muhd nor hazli nordin
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2005
url	https://ir.uitm.edu.my/id/eprint/98537/1/98537.PDF
_version_	1811768931264757760

Antimicrobial activity of Sindora bruggemanii (sepetir) oil / Muhd Nor Hazli Nordin

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