Impurity profiling of a drug substances / Nur Salima Shamsudin

Carbimazole is an antithyroid drug and is used in treating hyperthyroidism. Carbimazole itself is inactive, but it is rapidly converted to methimazole. This thesis described a thin layer chromatography (TLC) method and a validated high performance liquid chromatography (HPLC) detection method to ide...

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Main Author:	Shamsudin, Nur Salima
Format:	Thesis
Language:	English
Published:	2005
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/98630/1/98630.PDF
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id	my-uitm-ir.98630
record_format	uketd_dc
spelling	my-uitm-ir.986302024-07-22T08:44:10Z Impurity profiling of a drug substances / Nur Salima Shamsudin 2005 Shamsudin, Nur Salima RM Therapeutics. Pharmacology RS Pharmacy and materia medica Carbimazole is an antithyroid drug and is used in treating hyperthyroidism. Carbimazole itself is inactive, but it is rapidly converted to methimazole. This thesis described a thin layer chromatography (TLC) method and a validated high performance liquid chromatography (HPLC) detection method to identify and also to determine the amount of impurity present in carbimazole sample. Solvents used in TLC method were dichloromethane, chloroform and acetone as mobile phase. The TLC plate used was TLC aluminium sheets, 20 x 20 cm, Silica Gel 60 F254. The HPLC was equipped with column ZORBAX 300SB-CI8, 5 pm, dimension 4.6 x 150 mm, manual injector with 20pl loop and a UV detector. The separation was achieved using acetonitrile and water as mobile phase at a flow rate of 1.2 ml/min.The impurity and amount of carbimazole in carbimazole tablet were found. The limit of detection on TLC method was 1 mg/ml while for HPLC was 0.025 pg/ml. A suitable method was developed to identify and quantitate carbimazole compound and its impurity in carbimazole tablet. 2005 Thesis https://ir.uitm.edu.my/id/eprint/98630/ https://ir.uitm.edu.my/id/eprint/98630/1/98630.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mohd Shah, Ismail
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohd Shah, Ismail
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Shamsudin, Nur Salima Impurity profiling of a drug substances / Nur Salima Shamsudin
description	Carbimazole is an antithyroid drug and is used in treating hyperthyroidism. Carbimazole itself is inactive, but it is rapidly converted to methimazole. This thesis described a thin layer chromatography (TLC) method and a validated high performance liquid chromatography (HPLC) detection method to identify and also to determine the amount of impurity present in carbimazole sample. Solvents used in TLC method were dichloromethane, chloroform and acetone as mobile phase. The TLC plate used was TLC aluminium sheets, 20 x 20 cm, Silica Gel 60 F254. The HPLC was equipped with column ZORBAX 300SB-CI8, 5 pm, dimension 4.6 x 150 mm, manual injector with 20pl loop and a UV detector. The separation was achieved using acetonitrile and water as mobile phase at a flow rate of 1.2 ml/min.The impurity and amount of carbimazole in carbimazole tablet were found. The limit of detection on TLC method was 1 mg/ml while for HPLC was 0.025 pg/ml. A suitable method was developed to identify and quantitate carbimazole compound and its impurity in carbimazole tablet.
format	Thesis
qualification_level	Bachelor degree
author	Shamsudin, Nur Salima
author_facet	Shamsudin, Nur Salima
author_sort	Shamsudin, Nur Salima
title	Impurity profiling of a drug substances / Nur Salima Shamsudin
title_short	Impurity profiling of a drug substances / Nur Salima Shamsudin
title_full	Impurity profiling of a drug substances / Nur Salima Shamsudin
title_fullStr	Impurity profiling of a drug substances / Nur Salima Shamsudin
title_full_unstemmed	Impurity profiling of a drug substances / Nur Salima Shamsudin
title_sort	impurity profiling of a drug substances / nur salima shamsudin
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2005
url	https://ir.uitm.edu.my/id/eprint/98630/1/98630.PDF
_version_	1811768946868617216

Impurity profiling of a drug substances / Nur Salima Shamsudin

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