Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi

AIM: This study sets to investigate the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a rotatory viscometer and at a solut...

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Main Author:	Zabidi, Azreen Suzyliana
Format:	Thesis
Language:	English
Published:	2005
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/98634/1/98634.PDF
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id	my-uitm-ir.98634
record_format	uketd_dc
spelling	my-uitm-ir.986342024-07-22T08:19:55Z Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi 2005 Zabidi, Azreen Suzyliana RM Therapeutics. Pharmacology RS Pharmacy and materia medica AIM: This study sets to investigate the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a rotatory viscometer and at a solution temperatures of 30 to 60°C unless otherwise stated. The additives used were trisodium citrate, citric acid, triethylcitrate and triacetin. RESULT: The viscosity of aqueous HPMC solutions was reduced when appropriate amounts of trisodium citrate, citric acid, triethylcitrate and triacetin were added. Using 1% w/w HPMC solution, triethylcitrate demonstrated the best viscosity lowering effect when solution temperature of 30 to 50°C were concerned while trisodium citrate exhibited a marked viscosity lowering property at 60°C. Using 1.5% w/w HPMC solution, smaller additive such as citric acid gave rise to the most prominent viscosity lowering property. CONCLUSION: Trisodium citrate, citric acid, triethylcitrate and triacetin exhibited viscosity lowering property in HPMC solution. 2005 Thesis https://ir.uitm.edu.my/id/eprint/98634/ https://ir.uitm.edu.my/id/eprint/98634/1/98634.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Wui, Wong Tin
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wui, Wong Tin
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Zabidi, Azreen Suzyliana Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
description	AIM: This study sets to investigate the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a rotatory viscometer and at a solution temperatures of 30 to 60°C unless otherwise stated. The additives used were trisodium citrate, citric acid, triethylcitrate and triacetin. RESULT: The viscosity of aqueous HPMC solutions was reduced when appropriate amounts of trisodium citrate, citric acid, triethylcitrate and triacetin were added. Using 1% w/w HPMC solution, triethylcitrate demonstrated the best viscosity lowering effect when solution temperature of 30 to 50°C were concerned while trisodium citrate exhibited a marked viscosity lowering property at 60°C. Using 1.5% w/w HPMC solution, smaller additive such as citric acid gave rise to the most prominent viscosity lowering property. CONCLUSION: Trisodium citrate, citric acid, triethylcitrate and triacetin exhibited viscosity lowering property in HPMC solution.
format	Thesis
qualification_level	Bachelor degree
author	Zabidi, Azreen Suzyliana
author_facet	Zabidi, Azreen Suzyliana
author_sort	Zabidi, Azreen Suzyliana
title	Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_short	Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_full	Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_fullStr	Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_full_unstemmed	Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi
title_sort	effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / azreen suzyliana zabidi
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2005
url	https://ir.uitm.edu.my/id/eprint/98634/1/98634.PDF
_version_	1811768947890978816

Effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose solution / Azreen Suzyliana Zabidi

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