Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon

Sustained-release drug delivery systems allow the antifungal agent to reside at the sites of infection for a prolonged period; hence the systems are ideal to be applied topically in order to achieve desirable therapeutic effect. A simple, sensitive, rapid and reproducible assay method has been devel...

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Main Author:	Sa’adon, Sofiyyah
Format:	Thesis
Language:	English
Published:	2005
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/98650/1/98650.PDF
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id	my-uitm-ir.98650
record_format	uketd_dc
spelling	my-uitm-ir.986502024-07-22T04:35:58Z Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon 2005 Sa’adon, Sofiyyah RM Therapeutics. Pharmacology RS Pharmacy and materia medica Sustained-release drug delivery systems allow the antifungal agent to reside at the sites of infection for a prolonged period; hence the systems are ideal to be applied topically in order to achieve desirable therapeutic effect. A simple, sensitive, rapid and reproducible assay method has been developed for determination of the antifungal drug, clotrimazole, when it is incorporated with sodium carboxymethylcellulose as the polymer for sustained-release solid dosage form. Chromatographic method was applied by using high performance liquid chromatography (HPLC) equipped with reversed phase octadecylsilica (ODS) C l8 column. The compound was separated with the mobile phase comprised of acetonitrile and 25 mM disodium hydrogen phosphate anhydrous (65:35, v/v) adjusted to pH 8 with o- phosphoric acid. Analysis was run at a flow rate of 1.0 ml/min and the column effluent was monitored at a wavelength of 220 nm. The calibration graph was linear over the concentration range of 10-100 pg/ml with the retention time of 3.74 min. The correlation coefficient of the calibration curves were always >0.999, while the within- day and between-day coefficient of variation were all less than 1%. The developed method has been successfully applied for the determination of clotrimazole from its polymer. 2005 Thesis https://ir.uitm.edu.my/id/eprint/98650/ https://ir.uitm.edu.my/id/eprint/98650/1/98650.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Ramli, Nor Amlizan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ramli, Nor Amlizan
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Sa’adon, Sofiyyah Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon
description	Sustained-release drug delivery systems allow the antifungal agent to reside at the sites of infection for a prolonged period; hence the systems are ideal to be applied topically in order to achieve desirable therapeutic effect. A simple, sensitive, rapid and reproducible assay method has been developed for determination of the antifungal drug, clotrimazole, when it is incorporated with sodium carboxymethylcellulose as the polymer for sustained-release solid dosage form. Chromatographic method was applied by using high performance liquid chromatography (HPLC) equipped with reversed phase octadecylsilica (ODS) C l8 column. The compound was separated with the mobile phase comprised of acetonitrile and 25 mM disodium hydrogen phosphate anhydrous (65:35, v/v) adjusted to pH 8 with o- phosphoric acid. Analysis was run at a flow rate of 1.0 ml/min and the column effluent was monitored at a wavelength of 220 nm. The calibration graph was linear over the concentration range of 10-100 pg/ml with the retention time of 3.74 min. The correlation coefficient of the calibration curves were always >0.999, while the within- day and between-day coefficient of variation were all less than 1%. The developed method has been successfully applied for the determination of clotrimazole from its polymer.
format	Thesis
qualification_level	Bachelor degree
author	Sa’adon, Sofiyyah
author_facet	Sa’adon, Sofiyyah
author_sort	Sa’adon, Sofiyyah
title	Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon
title_short	Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon
title_full	Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon
title_fullStr	Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon
title_full_unstemmed	Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon
title_sort	development of assay method for clotrimazole as a sustained release solid dosage form / sofiyyah sa’adon
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2005
url	https://ir.uitm.edu.my/id/eprint/98650/1/98650.PDF
_version_	1811768950922412032

Development of assay method for clotrimazole as a sustained release solid dosage form / Sofiyyah Sa’adon

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