Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah

The main objective of this project is to synthesize a stilbene analogue, 4-acetoxy-l 1,13- dibenzyloxystilbene at large scale in order to supply for bioactivity and reactivity investigations by other researchers. Three established reactions have been used in order to accomplish the project. First, t...

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Bibliographic Details
Main Author:	Abu Samah, Nor Hayati
Format:	Thesis
Language:	English
Published:	2005
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/98657/1/98657.PDF
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id	my-uitm-ir.98657
record_format	uketd_dc
spelling	my-uitm-ir.986572024-07-22T08:02:14Z Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah 2005 Abu Samah, Nor Hayati RM Therapeutics. Pharmacology RS Pharmacy and materia medica The main objective of this project is to synthesize a stilbene analogue, 4-acetoxy-l 1,13- dibenzyloxystilbene at large scale in order to supply for bioactivity and reactivity investigations by other researchers. Three established reactions have been used in order to accomplish the project. First, the protection ofp-iodophenol using acetic anhydride to yield p-iodophenylacetale followed by the protection of 3,5-dihydroxybenzaldehyde with benzyl bromide that produced 3,5-dibenzyloxybenzaldehyde. Subsequently, the 3,5-dibenzyloxybenzaldehyde is utilized as a starting material of the Wittig reaction. Product of the Wittig reaction and /j-iodophenylaceate are then used to synthesize the stilbene analogue. The synthesized compounds are then, purified by chromatographic techniques and sent for 'H-NMR characterization. Concisely, even though the compound of desired has failed to be obtained, an almost structurally identical compound has been successfully synthesized in small amount. 2005 Thesis https://ir.uitm.edu.my/id/eprint/98657/ https://ir.uitm.edu.my/id/eprint/98657/1/98657.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Abdul Wahab, Ibtisam
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Wahab, Ibtisam
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Abu Samah, Nor Hayati Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
description	The main objective of this project is to synthesize a stilbene analogue, 4-acetoxy-l 1,13- dibenzyloxystilbene at large scale in order to supply for bioactivity and reactivity investigations by other researchers. Three established reactions have been used in order to accomplish the project. First, the protection ofp-iodophenol using acetic anhydride to yield p-iodophenylacetale followed by the protection of 3,5-dihydroxybenzaldehyde with benzyl bromide that produced 3,5-dibenzyloxybenzaldehyde. Subsequently, the 3,5-dibenzyloxybenzaldehyde is utilized as a starting material of the Wittig reaction. Product of the Wittig reaction and /j-iodophenylaceate are then used to synthesize the stilbene analogue. The synthesized compounds are then, purified by chromatographic techniques and sent for 'H-NMR characterization. Concisely, even though the compound of desired has failed to be obtained, an almost structurally identical compound has been successfully synthesized in small amount.
format	Thesis
qualification_level	Bachelor degree
author	Abu Samah, Nor Hayati
author_facet	Abu Samah, Nor Hayati
author_sort	Abu Samah, Nor Hayati
title	Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_short	Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_full	Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_fullStr	Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_full_unstemmed	Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah
title_sort	synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / nor hayati abu samah
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2005
url	https://ir.uitm.edu.my/id/eprint/98657/1/98657.PDF
_version_	1811768951675289600

Synthesis of 4-acetoxy-ll,13- dibenzyloxystilbene / Nor Hayati Abu Samah

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