Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli

In order to explore the dose respond effect on spatial memory and somatosensory after acute and chronic exposure of Monosodium Glutamate (MSG), adult rats were administered intraperitoneally with MSG for 21 days with dose 2.0 mg/g, 4.0 mg/g and 8.0 mg/g per body weight. Normal saline was administere...

Full description

Saved in:
Bibliographic Details
Main Author: Zulkupli, Muhammad Zulhafiz
Format: Thesis
Language:English
Published: 2006
Subjects:
Online Access:https://ir.uitm.edu.my/id/eprint/98879/1/98879.PDF
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-uitm-ir.98879
record_format uketd_dc
spelling my-uitm-ir.988792024-07-28T15:55:09Z Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli 2006 Zulkupli, Muhammad Zulhafiz RM Therapeutics. Pharmacology RS Pharmacy and materia medica In order to explore the dose respond effect on spatial memory and somatosensory after acute and chronic exposure of Monosodium Glutamate (MSG), adult rats were administered intraperitoneally with MSG for 21 days with dose 2.0 mg/g, 4.0 mg/g and 8.0 mg/g per body weight. Normal saline was administered intraperitoneally as control. In this study, the methodology for the validation of MSG effects on central nervous system and cognitive function has been applied. Spatial memory impairment was assessed with the use of Morris Water Maze (MWM) task. On the other hand, the somatosensory impairment was evaluated using the sticky-tape test whereby, animals were assessed according to their ability to remove the stimulus (sticky-tape). On day 1, 7, 14 and 21, Morris Water Maze and sticky-tape test were conducted in this study. No significant different in behavioral performance between the control and MSG treated rats were found in all paradigms which have been measured. In rats, such MSG treatment with doses of 2.0 mg/g and 4.0 mg/g do not cause statistically significant on spatial learning deficits in MWM task and also do not reveal any somatosensory dysfunction. Moreover it does not attribute to a subsequent increasing in body weight as reported in previous study. Additionally administration of very high concentration of MSG (8.0mg/g) caused hyperactivity of the glutamate system and induce convulsion after the treatment. These observations support that the ability of large, concentrated doses of MSG to produce brain lesions. Nevertheless this study does not really support and extends earlier study that MSG treatment produces behavioral changes. 2006 Thesis https://ir.uitm.edu.my/id/eprint/98879/ https://ir.uitm.edu.my/id/eprint/98879/1/98879.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Johari James, Richard Muhammad
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Johari James, Richard Muhammad
topic RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
Zulkupli, Muhammad Zulhafiz
Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli
description In order to explore the dose respond effect on spatial memory and somatosensory after acute and chronic exposure of Monosodium Glutamate (MSG), adult rats were administered intraperitoneally with MSG for 21 days with dose 2.0 mg/g, 4.0 mg/g and 8.0 mg/g per body weight. Normal saline was administered intraperitoneally as control. In this study, the methodology for the validation of MSG effects on central nervous system and cognitive function has been applied. Spatial memory impairment was assessed with the use of Morris Water Maze (MWM) task. On the other hand, the somatosensory impairment was evaluated using the sticky-tape test whereby, animals were assessed according to their ability to remove the stimulus (sticky-tape). On day 1, 7, 14 and 21, Morris Water Maze and sticky-tape test were conducted in this study. No significant different in behavioral performance between the control and MSG treated rats were found in all paradigms which have been measured. In rats, such MSG treatment with doses of 2.0 mg/g and 4.0 mg/g do not cause statistically significant on spatial learning deficits in MWM task and also do not reveal any somatosensory dysfunction. Moreover it does not attribute to a subsequent increasing in body weight as reported in previous study. Additionally administration of very high concentration of MSG (8.0mg/g) caused hyperactivity of the glutamate system and induce convulsion after the treatment. These observations support that the ability of large, concentrated doses of MSG to produce brain lesions. Nevertheless this study does not really support and extends earlier study that MSG treatment produces behavioral changes.
format Thesis
qualification_level Bachelor degree
author Zulkupli, Muhammad Zulhafiz
author_facet Zulkupli, Muhammad Zulhafiz
author_sort Zulkupli, Muhammad Zulhafiz
title Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli
title_short Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli
title_full Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli
title_fullStr Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli
title_full_unstemmed Dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / Muhammad Zulhafiz Zulkupli
title_sort dose respond effect on spatial memory and somatosensory after acute and chronic of monosodium glutamate exposure in adults rats / muhammad zulhafiz zulkupli
granting_institution Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department Faculty of Pharmacy
publishDate 2006
url https://ir.uitm.edu.my/id/eprint/98879/1/98879.PDF
_version_ 1811768966811484160