Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi

This research project aims to synthesize a stilbene analogue, 4-acetoxy-12- benzoyloxystilbene 1 via series of reactions. This study was carried out in four established reactions. Firstly, starting from 4-iodophenol, the substance undergo protection of hydroxy 1 group into 4-iodophenylbenzoate. Then...

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Main Author:	Sanusi, Mohd Firdaus
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/98881/1/98881.PDF
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id	my-uitm-ir.98881
record_format	uketd_dc
spelling	my-uitm-ir.988812024-07-28T15:55:13Z Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi 2006 Sanusi, Mohd Firdaus RM Therapeutics. Pharmacology RS Pharmacy and materia medica This research project aims to synthesize a stilbene analogue, 4-acetoxy-12- benzoyloxystilbene 1 via series of reactions. This study was carried out in four established reactions. Firstly, starting from 4-iodophenol, the substance undergo protection of hydroxy 1 group into 4-iodophenylbenzoate. Then another starting material, 4-hydroxybenzaldehyde was protected by adding the acetoxy group to produce 4- acetoxybenzaldehyde followed by the Wittig reaction to develop 4-acetoxystyrene. The product from the Wittig reaction and 4-iodophenylbenzoate is utilized to synthesize the desired compound, 4-acetoxy-12-benzoyloxystilbene 1 by Heck reaction that involves the use of palladium (II) catalyst, triphenylphosphine ligand, argentum nitrate, potassium acetate and dimethylformamide solvent The products were purified by chromatographic technique by the use of thin layer chromatography plate. UV spectrophotometer and NMR characterization also had been used in the determination of the structure. However, the expected compound to be synthesized were not successfully obtained. Instead an almost structurally identical compound has been synthesized in small amount (18.8%). 2006 Thesis https://ir.uitm.edu.my/id/eprint/98881/ https://ir.uitm.edu.my/id/eprint/98881/1/98881.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Abdul Wahab, lbtisam
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Wahab, lbtisam
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Sanusi, Mohd Firdaus Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi
description	This research project aims to synthesize a stilbene analogue, 4-acetoxy-12- benzoyloxystilbene 1 via series of reactions. This study was carried out in four established reactions. Firstly, starting from 4-iodophenol, the substance undergo protection of hydroxy 1 group into 4-iodophenylbenzoate. Then another starting material, 4-hydroxybenzaldehyde was protected by adding the acetoxy group to produce 4- acetoxybenzaldehyde followed by the Wittig reaction to develop 4-acetoxystyrene. The product from the Wittig reaction and 4-iodophenylbenzoate is utilized to synthesize the desired compound, 4-acetoxy-12-benzoyloxystilbene 1 by Heck reaction that involves the use of palladium (II) catalyst, triphenylphosphine ligand, argentum nitrate, potassium acetate and dimethylformamide solvent The products were purified by chromatographic technique by the use of thin layer chromatography plate. UV spectrophotometer and NMR characterization also had been used in the determination of the structure. However, the expected compound to be synthesized were not successfully obtained. Instead an almost structurally identical compound has been synthesized in small amount (18.8%).
format	Thesis
qualification_level	Bachelor degree
author	Sanusi, Mohd Firdaus
author_facet	Sanusi, Mohd Firdaus
author_sort	Sanusi, Mohd Firdaus
title	Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi
title_short	Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi
title_full	Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi
title_fullStr	Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi
title_full_unstemmed	Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi
title_sort	synthesis of 4-acetoxy-12-benzoyloxystilbene / mohd firdaus sanusi
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/98881/1/98881.PDF
_version_	1811768967065239552

Synthesis of 4-acetoxy-12-benzoyloxystilbene / Mohd Firdaus Sanusi

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