Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil

The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, trans 4-methoxy-4' -brornomethyl stilbene appended onto Zn(Il)-cyclen complex. Three established reactions had been used in order to accomplish this research study. For the first reaction, the 4-methoxy...

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Main Author:	Che Wil, Fitriah Cahyani
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/98929/1/98929.PDF
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id	my-uitm-ir.98929
record_format	uketd_dc
spelling	my-uitm-ir.989292024-07-28T15:57:49Z Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil 2006 Che Wil, Fitriah Cahyani RM Therapeutics. Pharmacology RS Pharmacy and materia medica The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, trans 4-methoxy-4' -brornomethyl stilbene appended onto Zn(Il)-cyclen complex. Three established reactions had been used in order to accomplish this research study. For the first reaction, the 4-methoxy styrene and 4-iodobenzylbromide was utilized as a starting material of Heck reaction to synthesis trans 4-methoxy-4'-bromornethyl stilbene. The synthesis compound was then purified by silica gel column chromatography technique and sent for H-NMR and FT-IR characterization in order to confirm the product structure. The second step is to obtain 1,4, 7, 10-tetraazacyclododecane ( cyclen) by performing dechclorinated reaction of cyclen tetrahydrochloride and then followed by cyclen protection reaction with tert-butyloxycarbonyl (Boe anhydride) to produce 1,4,7-tris(tert-butyloxycarbonyl)-l ,4, 7, 10-tetraazacyclododecane. Subsequently, the third reaction was performed by appending the resveratrol analogue, trans 4-methoxy-4' - bromomethyl stilbene onto protected cyclen, tri-Boc cyclen. Nevertheless, the outcomes of this research study did not make the grade because no final product has been produced (resveratrol Zn(Il)-cyclen complex) and the research was postponed due to the time constraint. 2006 Thesis https://ir.uitm.edu.my/id/eprint/98929/ https://ir.uitm.edu.my/id/eprint/98929/1/98929.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mat Jusoh, Mohd Zulkefeli Faizal Weber, Jean-Frederic
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mat Jusoh, Mohd Zulkefeli Faizal Weber, Jean-Frederic
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Che Wil, Fitriah Cahyani Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil
description	The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, trans 4-methoxy-4' -brornomethyl stilbene appended onto Zn(Il)-cyclen complex. Three established reactions had been used in order to accomplish this research study. For the first reaction, the 4-methoxy styrene and 4-iodobenzylbromide was utilized as a starting material of Heck reaction to synthesis trans 4-methoxy-4'-bromornethyl stilbene. The synthesis compound was then purified by silica gel column chromatography technique and sent for H-NMR and FT-IR characterization in order to confirm the product structure. The second step is to obtain 1,4, 7, 10-tetraazacyclododecane ( cyclen) by performing dechclorinated reaction of cyclen tetrahydrochloride and then followed by cyclen protection reaction with tert-butyloxycarbonyl (Boe anhydride) to produce 1,4,7-tris(tert-butyloxycarbonyl)-l ,4, 7, 10-tetraazacyclododecane. Subsequently, the third reaction was performed by appending the resveratrol analogue, trans 4-methoxy-4' - bromomethyl stilbene onto protected cyclen, tri-Boc cyclen. Nevertheless, the outcomes of this research study did not make the grade because no final product has been produced (resveratrol Zn(Il)-cyclen complex) and the research was postponed due to the time constraint.
format	Thesis
qualification_level	Bachelor degree
author	Che Wil, Fitriah Cahyani
author_facet	Che Wil, Fitriah Cahyani
author_sort	Che Wil, Fitriah Cahyani
title	Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil
title_short	Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil
title_full	Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil
title_fullStr	Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil
title_full_unstemmed	Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil
title_sort	design and synthesis of resveratrol zinc(ii)-cyclen complex (analogue i) / fitriah cahy ani che wil
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/98929/1/98929.PDF
_version_	1811768968847818752

Design and synthesis of resveratrol zinc(II)-cyclen complex (analogue I) / Fitriah Cahy Ani Che Wil

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