Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman

Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman

The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, 3-methoxy-4'-bromomethyl stilbene appended onto Zn2+-cyclen complex. Three established reactions have been used in order to accomplish this research study. For the first reaction, the 3-methoxy styrene...

Full description

Saved in:
Bibliographic Details
Main Author: Othman, Ezazaya
Format: Thesis
Language:English
Published: 2006
Subjects:
RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
Online Access:https://ir.uitm.edu.my/id/eprint/98938/1/98938.PDF
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-uitm-ir.98938
record_format uketd_dc
spelling my-uitm-ir.989382024-07-24T08:06:26Z Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman 2006 Othman, Ezazaya RM Therapeutics. Pharmacology RS Pharmacy and materia medica The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, 3-methoxy-4'-bromomethyl stilbene appended onto Zn2+-cyclen complex. Three established reactions have been used in order to accomplish this research study. For the first reaction, the 3-methoxy styrene and 4-iodobenzyl bromide was utilized as a starting material of Heck reaction to synthesis trans 3-methoxy-4' -bromomethyl stilbene. The synthesis compound was then purified by silica gel column chromatography technique and sent for 1H-NMR and FT-IR characterization in order to confirm the product structure. The second step is to obtain 1,4,7,10-tetraazacyclododecane (cyclen) by performing dechlorinated reaction of cyclen tetrahydrochloride, followed by cyclen protection reaction with tert-butyloxycarbonyl (Boe anhydride) to produce 1,4,7- tris(tert-butyloxycarbonyl)-1,4, 7, 10-tetraazacyclododecane. Subsequently, the third reaction was performed by appending the resveratrol analogue, trans 3-methoxy-4'­ bromomethyl stilbene onto protected cyclen, 3 Boc-cyclen. Nevertheless, the outcomes of this research study did not make the grade because no final product has been produced (resveratrol Zn2+-cyclen complex) and the research was postponed due to the time constraint. 2006 Thesis https://ir.uitm.edu.my/id/eprint/98938/ https://ir.uitm.edu.my/id/eprint/98938/1/98938.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mat Jusoh, Mohd Zulkefeli
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Mat Jusoh, Mohd Zulkefeli
topic RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
Othman, Ezazaya
Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman
description The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, 3-methoxy-4'-bromomethyl stilbene appended onto Zn2+-cyclen complex. Three established reactions have been used in order to accomplish this research study. For the first reaction, the 3-methoxy styrene and 4-iodobenzyl bromide was utilized as a starting material of Heck reaction to synthesis trans 3-methoxy-4' -bromomethyl stilbene. The synthesis compound was then purified by silica gel column chromatography technique and sent for 1H-NMR and FT-IR characterization in order to confirm the product structure. The second step is to obtain 1,4,7,10-tetraazacyclododecane (cyclen) by performing dechlorinated reaction of cyclen tetrahydrochloride, followed by cyclen protection reaction with tert-butyloxycarbonyl (Boe anhydride) to produce 1,4,7- tris(tert-butyloxycarbonyl)-1,4, 7, 10-tetraazacyclododecane. Subsequently, the third reaction was performed by appending the resveratrol analogue, trans 3-methoxy-4'­ bromomethyl stilbene onto protected cyclen, 3 Boc-cyclen. Nevertheless, the outcomes of this research study did not make the grade because no final product has been produced (resveratrol Zn2+-cyclen complex) and the research was postponed due to the time constraint.
format Thesis
qualification_level Bachelor degree
author Othman, Ezazaya
author_facet Othman, Ezazaya
author_sort Othman, Ezazaya
title Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman
title_short Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman
title_full Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman
title_fullStr Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman
title_full_unstemmed Design and synthesis of resvera trol-zn(II)-cyclen complex analogue II / Ezazaya Othman
title_sort design and synthesis of resvera trol-zn(ii)-cyclen complex analogue ii / ezazaya othman
granting_institution Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department Faculty of Pharmacy
publishDate 2006
url https://ir.uitm.edu.my/id/eprint/98938/1/98938.PDF
_version_ 1811768970374545408

Similar Items