Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali

The antidiabetic effect of an aqueous extract of Eugenia polyantha (Myrthaceae) was investigated in normal and streptozotocin-induced diabetic male adult albino Sprague Dawley rats. In the present study, rats were pretreated with an aqueous extract of Eugenia polyantha (0.5 and 0.05 g/kg body weigh...

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Main Author:	Ali, Noor Azline
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99034/1/99034.PDF
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id	my-uitm-ir.99034
record_format	uketd_dc
spelling	my-uitm-ir.990342024-07-24T03:14:45Z Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali 2006 Ali, Noor Azline RM Therapeutics. Pharmacology RS Pharmacy and materia medica The antidiabetic effect of an aqueous extract of Eugenia polyantha (Myrthaceae) was investigated in normal and streptozotocin-induced diabetic male adult albino Sprague Dawley rats. In the present study, rats were pretreated with an aqueous extract of Eugenia polyantha (0.5 and 0.05 g/kg body weight oral administration daily) for 14 days and then subjected to diabetic induction with a single intraperitoneal dose of STZ (55 mg/kg body weight). After 7 days, rats were sacrificed for blood and organ collection. Blood samples were used for determination of fasting blood glucose, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Throughout the experiment, the rat weights, water and food intake and relative weight of organs were determined. The STZ-induced diabetic rats given 0.5 and 0.05 g/kg body weight of EP showed no significant improvement in controlling body weights, food and water consumption and hyperglycemia compared to diabetic control rats. Both doses (0.5 and 0.05 g/kg body weight of EP) caused death in normal rats. Diabetic control rats showed significant lost in body weight, increased water consumption and hyperglycemia compared to normal rats. No effect of STZ and EP showed on organs (lungs, livers, hearts and kidneys), ALT and AST levels. These results suggest that the aqueous extract of Eugenia polyantha (Myrthaceae) had less antidiabetic effect if consumed before diabetes induction in rats. Hypothesis of Eugenia polyantha reducing blood glucose levels by a dose-dependent manner in STZ-induced diabetic rats has not been proven. This study also showed that 55 mg/kg body weight of STZ increases blood glucose of rats. 2006 Thesis https://ir.uitm.edu.my/id/eprint/99034/ https://ir.uitm.edu.my/id/eprint/99034/1/99034.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Adam, Aishah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Adam, Aishah
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Ali, Noor Azline Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali
description	The antidiabetic effect of an aqueous extract of Eugenia polyantha (Myrthaceae) was investigated in normal and streptozotocin-induced diabetic male adult albino Sprague Dawley rats. In the present study, rats were pretreated with an aqueous extract of Eugenia polyantha (0.5 and 0.05 g/kg body weight oral administration daily) for 14 days and then subjected to diabetic induction with a single intraperitoneal dose of STZ (55 mg/kg body weight). After 7 days, rats were sacrificed for blood and organ collection. Blood samples were used for determination of fasting blood glucose, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Throughout the experiment, the rat weights, water and food intake and relative weight of organs were determined. The STZ-induced diabetic rats given 0.5 and 0.05 g/kg body weight of EP showed no significant improvement in controlling body weights, food and water consumption and hyperglycemia compared to diabetic control rats. Both doses (0.5 and 0.05 g/kg body weight of EP) caused death in normal rats. Diabetic control rats showed significant lost in body weight, increased water consumption and hyperglycemia compared to normal rats. No effect of STZ and EP showed on organs (lungs, livers, hearts and kidneys), ALT and AST levels. These results suggest that the aqueous extract of Eugenia polyantha (Myrthaceae) had less antidiabetic effect if consumed before diabetes induction in rats. Hypothesis of Eugenia polyantha reducing blood glucose levels by a dose-dependent manner in STZ-induced diabetic rats has not been proven. This study also showed that 55 mg/kg body weight of STZ increases blood glucose of rats.
format	Thesis
qualification_level	Bachelor degree
author	Ali, Noor Azline
author_facet	Ali, Noor Azline
author_sort	Ali, Noor Azline
title	Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali
title_short	Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali
title_full	Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali
title_fullStr	Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali
title_full_unstemmed	Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali
title_sort	determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / noor azline ali
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/99034/1/99034.PDF
_version_	1811768975678242816

Determination of antidiabetic effect of eugenia polyantha using streptozotocin-induced diabetic rats / Noor Azline Ali

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