Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri
This study was designed to compare the absorption profiles of nano-emulsion containing n-tocopherol formulated with three different oils, i.e. palm oil, soybean oil and VCO in Sprague-Dawley rats. The plasma concentration of n-tocopherol was determined at specific intervals up to 36 hours post admin...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2006
|
| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/99036/1/99036.PDF |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
my-uitm-ir.99036 |
|---|---|
| record_format |
uketd_dc |
| spelling |
my-uitm-ir.990362024-07-24T03:14:43Z Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri 2006 Mazri, Murniati RM Therapeutics. Pharmacology RS Pharmacy and materia medica This study was designed to compare the absorption profiles of nano-emulsion containing n-tocopherol formulated with three different oils, i.e. palm oil, soybean oil and VCO in Sprague-Dawley rats. The plasma concentration of n-tocopherol was determined at specific intervals up to 36 hours post administration of formulations with a dose of 30 TIJ/kg of tocopherol. The peak heights were obtained by direct injection of plasma samples into the High Performance Liquid Chromatography (HPLC), after being deproteinized. The total absorption of the n-tocopherol, calculated as the total area under the plasma concentration time curve (AUCo-∞), was markedly greatest for the palm oil, followed by soybean oil and VCO formulation. This study also showed a rapid absorption of n-tocopherol from oils containing long chain fatty acids (palm oil and soybean oil) compared to the medium chain triglyceride oil (VCO). Although apparently AUCo-∞ and Cmax of nano-emulsion of c-tocopherol formulated in palm oil is higher than in soybean oil and in VCO, they were not significantly different when analysed by a one-way analysis of variance (ANOV A). From the results obtained, it can be concluded that palm oil provides better absorption of c-tocopherol when being formulated as nano-emulsion, when compared to other oils (soybean oil and VCO). 2006 Thesis https://ir.uitm.edu.my/id/eprint/99036/ https://ir.uitm.edu.my/id/eprint/99036/1/99036.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Bustami Effendi, Tommy Julianto |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
Bustami Effendi, Tommy Julianto |
| topic |
RM Therapeutics Pharmacology RS Pharmacy and materia medica |
| spellingShingle |
RM Therapeutics Pharmacology RS Pharmacy and materia medica Mazri, Murniati Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri |
| description |
This study was designed to compare the absorption profiles of nano-emulsion containing n-tocopherol formulated with three different oils, i.e. palm oil, soybean oil and VCO in Sprague-Dawley rats. The plasma concentration of n-tocopherol was determined at specific intervals up to 36 hours post administration of formulations with a dose of 30 TIJ/kg of tocopherol. The peak heights were obtained by direct injection of plasma samples into the High Performance Liquid Chromatography (HPLC), after being deproteinized. The total absorption of the n-tocopherol, calculated as the total area under the plasma concentration time curve (AUCo-∞), was markedly greatest for the palm oil, followed by soybean oil and VCO formulation. This study also showed a rapid absorption of n-tocopherol from oils containing long chain fatty acids (palm oil and soybean oil) compared to the medium chain triglyceride oil (VCO). Although apparently AUCo-∞ and Cmax of nano-emulsion of c-tocopherol formulated in palm oil is higher than in soybean oil and in VCO, they were not significantly different when analysed by a one-way analysis of variance (ANOV A). From the results obtained, it can be concluded that palm oil provides better absorption of c-tocopherol when being formulated as nano-emulsion, when compared to other oils (soybean oil and VCO). |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Mazri, Murniati |
| author_facet |
Mazri, Murniati |
| author_sort |
Mazri, Murniati |
| title |
Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri |
| title_short |
Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri |
| title_full |
Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri |
| title_fullStr |
Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri |
| title_full_unstemmed |
Pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / Murniati Mazri |
| title_sort |
pharmacokinetic profile of a-tocopherol in three different nano-emulsion formulations in rats / murniati mazri |
| granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
| granting_department |
Faculty of Pharmacy |
| publishDate |
2006 |
| url |
https://ir.uitm.edu.my/id/eprint/99036/1/99036.PDF |
| _version_ |
1811768975934095360 |