Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff

The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, 3,4-dimethoxy-4' -bromornethyl stilbene appended onto Zn(II)-cyclen complex. Three established reaction had been used in order to accomplish this research study. For the first reaction, the 3,4-dimethox...

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Main Author:	Yusoff, Rozida
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99038/1/99038.PDF
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id	my-uitm-ir.99038
record_format	uketd_dc
spelling	my-uitm-ir.990382024-07-24T03:07:54Z Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff 2006 Yusoff, Rozida RM Therapeutics. Pharmacology RS Pharmacy and materia medica The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, 3,4-dimethoxy-4' -bromornethyl stilbene appended onto Zn(II)-cyclen complex. Three established reaction had been used in order to accomplish this research study. For the first reaction, the 3,4-dimethoxy styrene and 4-iodobenzylbromide was utilizes as a starting material of Heck reaction to synthesis trans 3,4-dimethoxy-4'-bromomethyl stilbene. The synthesis compound was then purified by silica gel column chromatography technique and sent for 1H-NMR and FT-IR characterization in order to confirm the product structure. The second step is, the 1,4,7,10-tetraazacyclododecane (cyclen) obtained by dechlorinated of tetrachlorinated cyclen and then followed by protected cyclen with tert-butyloxycarbonyl to produced 1,4, 7-tris (tert butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane. Subsequently, the third reaction was done by appended resveratrol analogue, trans 3,5-dimethoxy-4'-brornomethyl stilbene to protected cyclen, triboc-cyclen. But the outcomes of this research study did not make the grade, it is because no final product has been produced (resveratrol Zn(II)-cyclen complex) and the research was postponed due to time constraint. 2006 Thesis https://ir.uitm.edu.my/id/eprint/99038/ https://ir.uitm.edu.my/id/eprint/99038/1/99038.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mat Jusoh, Mohd Zulkefeli
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mat Jusoh, Mohd Zulkefeli
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Yusoff, Rozida Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff
description	The significant of this study is to design and synthesis of resveratrol (stilbene) analogue, 3,4-dimethoxy-4' -bromornethyl stilbene appended onto Zn(II)-cyclen complex. Three established reaction had been used in order to accomplish this research study. For the first reaction, the 3,4-dimethoxy styrene and 4-iodobenzylbromide was utilizes as a starting material of Heck reaction to synthesis trans 3,4-dimethoxy-4'-bromomethyl stilbene. The synthesis compound was then purified by silica gel column chromatography technique and sent for 1H-NMR and FT-IR characterization in order to confirm the product structure. The second step is, the 1,4,7,10-tetraazacyclododecane (cyclen) obtained by dechlorinated of tetrachlorinated cyclen and then followed by protected cyclen with tert-butyloxycarbonyl to produced 1,4, 7-tris (tert butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane. Subsequently, the third reaction was done by appended resveratrol analogue, trans 3,5-dimethoxy-4'-brornomethyl stilbene to protected cyclen, triboc-cyclen. But the outcomes of this research study did not make the grade, it is because no final product has been produced (resveratrol Zn(II)-cyclen complex) and the research was postponed due to time constraint.
format	Thesis
qualification_level	Bachelor degree
author	Yusoff, Rozida
author_facet	Yusoff, Rozida
author_sort	Yusoff, Rozida
title	Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff
title_short	Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff
title_full	Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff
title_fullStr	Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff
title_full_unstemmed	Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff
title_sort	design and synthesis of resveratrol zinc (ii)-cyclen complex (analogue iii) / rozida yusoff
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/99038/1/99038.PDF
_version_	1811768976460480512

Design and synthesis of resveratrol zinc (II)-cyclen complex (analogue III) / Rozida Yusoff

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