Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah

Currently, among the lead compounds studied in search for more potent drugs with few or no side effects, stilbene outstands for its promising therapeutic value. Various stilbene analogues have been studied for their chemical and biological properties. Catalytic Mizoroki-Heck reaction is claimed amon...

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Main Author:	Maasah, Ros Azima
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99042/1/99042.PDF
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id	my-uitm-ir.99042
record_format	uketd_dc
spelling	my-uitm-ir.990422024-07-24T03:07:46Z Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah 2006 Maasah, Ros Azima RM Therapeutics. Pharmacology RS Pharmacy and materia medica Currently, among the lead compounds studied in search for more potent drugs with few or no side effects, stilbene outstands for its promising therapeutic value. Various stilbene analogues have been studied for their chemical and biological properties. Catalytic Mizoroki-Heck reaction is claimed among the prominent approaches to synthesise stilbene. However, isomers are reported to form. Thus, regioselectivity become the concern of most studies. With appropriate reaction condition, regioselectivity is claimed achievable. Preformed active species of Pd is claimed preferable rather than attempting to generate active species in situ. This study is carried out to synthesise a stilbene analogue, trans-3,4-dimethoxy-11-benzyloxystilbene ! using Heck reaction with several reaction conditions and to observe effect of using preformed Pd(O) and in situ Pd(II) on yield of ]. ! was characterised using spectroscopy method (IR and NMR). Melting point of! was also determined. All reaction conditions chosen were appropriate to synthesise !. However, valid comparison between the yield of generated active species in situ and preformed active species from a Pd(O) or Pd(II) source cannot be compared. This is because the quantification method chosen are inappropriate. Thus, it is concluded that not only appropriate reaction condition is needed for regioselectivity, but appropriate quantification method also needs to be considered. 2006 Thesis https://ir.uitm.edu.my/id/eprint/99042/ https://ir.uitm.edu.my/id/eprint/99042/1/99042.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Abdul Wahab, lbtisam
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Wahab, lbtisam
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Maasah, Ros Azima Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah
description	Currently, among the lead compounds studied in search for more potent drugs with few or no side effects, stilbene outstands for its promising therapeutic value. Various stilbene analogues have been studied for their chemical and biological properties. Catalytic Mizoroki-Heck reaction is claimed among the prominent approaches to synthesise stilbene. However, isomers are reported to form. Thus, regioselectivity become the concern of most studies. With appropriate reaction condition, regioselectivity is claimed achievable. Preformed active species of Pd is claimed preferable rather than attempting to generate active species in situ. This study is carried out to synthesise a stilbene analogue, trans-3,4-dimethoxy-11-benzyloxystilbene ! using Heck reaction with several reaction conditions and to observe effect of using preformed Pd(O) and in situ Pd(II) on yield of ]. ! was characterised using spectroscopy method (IR and NMR). Melting point of! was also determined. All reaction conditions chosen were appropriate to synthesise !. However, valid comparison between the yield of generated active species in situ and preformed active species from a Pd(O) or Pd(II) source cannot be compared. This is because the quantification method chosen are inappropriate. Thus, it is concluded that not only appropriate reaction condition is needed for regioselectivity, but appropriate quantification method also needs to be considered.
format	Thesis
qualification_level	Bachelor degree
author	Maasah, Ros Azima
author_facet	Maasah, Ros Azima
author_sort	Maasah, Ros Azima
title	Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah
title_short	Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah
title_full	Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah
title_fullStr	Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah
title_full_unstemmed	Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah
title_sort	synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / ros azima maasah
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/99042/1/99042.PDF
_version_	1811768977221746688

Synthesis of trans-3,4-dimethoxy-11-benzyloxystilbene / Ros Azima Maasah

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