Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad

The leaves of mitragyna spectosa (Rubiaceae) have been traditionally used as substitute for opium. Mitragynine is a major alkaloid constituent that is known to produce opioid like action when smoked, chewed or drunk. This study is done to evaluate analgesic properties of mitragyna speciosa in mice....

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Main Author:	Mohd Saad, Salina
Format:	Thesis
Language:	English
Published:	2006
Subjects:	Drugs and their actions RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99082/1/99082.PDF
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id	my-uitm-ir.99082
record_format	uketd_dc
spelling	my-uitm-ir.990822024-07-24T03:17:18Z Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad 2006 Mohd Saad, Salina Drugs and their actions RS Pharmacy and materia medica The leaves of mitragyna spectosa (Rubiaceae) have been traditionally used as substitute for opium. Mitragynine is a major alkaloid constituent that is known to produce opioid like action when smoked, chewed or drunk. This study is done to evaluate analgesic properties of mitragyna speciosa in mice. Investigation of the antinociceptive activity of intraperitoneal (i.p) injection of saline, Mitragyna speciosa extract (l5mg/kg, 25mg/kg and 35mg/kg) and acetaminophen (35mg/kg) was done by using hot-plate test. The mice was placed on a metal plate maintained 55 ± 0.5°C and latency to show nociceptive responses such as hind paw licking, hind paw flicking or jumping was measured 5 minutes prior dosing and every 10 minutes over 80 minutes after dosing. Mitragyna speciosa showed increase in latency reaction compare to saline (control). However the results were not statistically significant .The test did not exhibit a dose dependent pattern. The latency time of mitragyna speciosa 15mg/kg was longer than Mitragyna speciosa 35mg/kg. Mitragyna speciosa may be a potential new analgesic. Nevertheless further studies need to be carried out in future to more understand its pharmacological properties. 2006 Thesis https://ir.uitm.edu.my/id/eprint/99082/ https://ir.uitm.edu.my/id/eprint/99082/1/99082.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Suratman, Nur Suraya Adina
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Suratman, Nur Suraya Adina
topic	Drugs and their actions RS Pharmacy and materia medica
spellingShingle	Drugs and their actions RS Pharmacy and materia medica Mohd Saad, Salina Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad
description	The leaves of mitragyna spectosa (Rubiaceae) have been traditionally used as substitute for opium. Mitragynine is a major alkaloid constituent that is known to produce opioid like action when smoked, chewed or drunk. This study is done to evaluate analgesic properties of mitragyna speciosa in mice. Investigation of the antinociceptive activity of intraperitoneal (i.p) injection of saline, Mitragyna speciosa extract (l5mg/kg, 25mg/kg and 35mg/kg) and acetaminophen (35mg/kg) was done by using hot-plate test. The mice was placed on a metal plate maintained 55 ± 0.5°C and latency to show nociceptive responses such as hind paw licking, hind paw flicking or jumping was measured 5 minutes prior dosing and every 10 minutes over 80 minutes after dosing. Mitragyna speciosa showed increase in latency reaction compare to saline (control). However the results were not statistically significant .The test did not exhibit a dose dependent pattern. The latency time of mitragyna speciosa 15mg/kg was longer than Mitragyna speciosa 35mg/kg. Mitragyna speciosa may be a potential new analgesic. Nevertheless further studies need to be carried out in future to more understand its pharmacological properties.
format	Thesis
qualification_level	Bachelor degree
author	Mohd Saad, Salina
author_facet	Mohd Saad, Salina
author_sort	Mohd Saad, Salina
title	Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad
title_short	Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad
title_full	Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad
title_fullStr	Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad
title_full_unstemmed	Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad
title_sort	evaluation of mitragyna speciosa analgesic activity in mice / salina mohd saad
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/99082/1/99082.PDF
_version_	1811768979719454720

Evaluation of mitragyna speciosa analgesic activity in mice / Salina Mohd Saad

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