Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi

Eugenia Polyantha (EP) belongs to Myrthaceae family that is widely distributed in Burma, lndo-China, Thailand, Malaysia, and Indonesia (Java, Sumatra, and Kalimantan). It is known for its traditional uses amongst Indonesians in the treatment of high cholesterol, diabetes, high blood pressure, stomac...

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Main Author:	Mohd Shahimi, Masdiana
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99084/1/99084.PDF
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id	my-uitm-ir.99084
record_format	uketd_dc
spelling	my-uitm-ir.990842024-07-24T03:54:33Z Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi 2006 Mohd Shahimi, Masdiana RM Therapeutics. Pharmacology RS Pharmacy and materia medica Eugenia Polyantha (EP) belongs to Myrthaceae family that is widely distributed in Burma, lndo-China, Thailand, Malaysia, and Indonesia (Java, Sumatra, and Kalimantan). It is known for its traditional uses amongst Indonesians in the treatment of high cholesterol, diabetes, high blood pressure, stomach disorder, and diarrhea. There are studies which reported on its hypoglycemic effect, antiparasitic activity and anti-tumor promoting activity. The leaves is said to contain essential oils, flavonoids, tannins, saponin, steroid, terpenoid and alkaloids. This study was to conduct an acute toxicity test and a subacute toxicity test to identify the effects of Eugenia polyantha extract on the blood parameters in rats. Mortality and clinical signs of toxicity were also monitored. ln the acute toxicity study no changes in the blood parameters were observed. Neither mortality nor toxicity effect were observed. In the subacute study, some mortality and signs of mild toxicity were observed in treated rats. The differential count of lymphocytes was significantly increased, while that of neutrophils was significantly reduced in the treatment group. This represented a shift in the immune response. Significant increase in ALT and significant decrease in albumin level in the treatment group could suggest impairment of liver function. In conclusion, the acute dose of Eugenia polyantha extract did not result in changes in the blood parameters and no clinical signs of toxicity were observed. However, the subacute dose did result in mortality, a shift in the response of the immune system and impairment of liver functions. 2006 Thesis https://ir.uitm.edu.my/id/eprint/99084/ https://ir.uitm.edu.my/id/eprint/99084/1/99084.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sulong, Adnan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sulong, Adnan
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Mohd Shahimi, Masdiana Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi
description	Eugenia Polyantha (EP) belongs to Myrthaceae family that is widely distributed in Burma, lndo-China, Thailand, Malaysia, and Indonesia (Java, Sumatra, and Kalimantan). It is known for its traditional uses amongst Indonesians in the treatment of high cholesterol, diabetes, high blood pressure, stomach disorder, and diarrhea. There are studies which reported on its hypoglycemic effect, antiparasitic activity and anti-tumor promoting activity. The leaves is said to contain essential oils, flavonoids, tannins, saponin, steroid, terpenoid and alkaloids. This study was to conduct an acute toxicity test and a subacute toxicity test to identify the effects of Eugenia polyantha extract on the blood parameters in rats. Mortality and clinical signs of toxicity were also monitored. ln the acute toxicity study no changes in the blood parameters were observed. Neither mortality nor toxicity effect were observed. In the subacute study, some mortality and signs of mild toxicity were observed in treated rats. The differential count of lymphocytes was significantly increased, while that of neutrophils was significantly reduced in the treatment group. This represented a shift in the immune response. Significant increase in ALT and significant decrease in albumin level in the treatment group could suggest impairment of liver function. In conclusion, the acute dose of Eugenia polyantha extract did not result in changes in the blood parameters and no clinical signs of toxicity were observed. However, the subacute dose did result in mortality, a shift in the response of the immune system and impairment of liver functions.
format	Thesis
qualification_level	Bachelor degree
author	Mohd Shahimi, Masdiana
author_facet	Mohd Shahimi, Masdiana
author_sort	Mohd Shahimi, Masdiana
title	Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi
title_short	Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi
title_full	Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi
title_fullStr	Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi
title_full_unstemmed	Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi
title_sort	effects of indigenous plant eugenia polyantha extract on blood parameters in rats / masdiana mohd shahimi
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/99084/1/99084.PDF
_version_	1811768980221722624

Effects of indigenous plant eugenia polyantha extract on blood parameters in rats / Masdiana Mohd Shahimi

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