Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman

Schisandra chinensis was famously used in the Chinese traditional medicines as hepatoprotective, antioxidant, physical performance improvement and anticarcinogenic. This study was designed to determine the toxic fraction of Schisandra chinensis. In an acute toxicity test, the single dose of 200, 400...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Ab Rahman, Norul Izza
التنسيق: أطروحة
اللغة:English
منشور في: 2006
الموضوعات:
الوصول للمادة أونلاين:https://ir.uitm.edu.my/id/eprint/99088/1/99088.PDF
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spelling my-uitm-ir.990882024-07-24T03:39:32Z Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman 2006 Ab Rahman, Norul Izza RM Therapeutics. Pharmacology RS Pharmacy and materia medica Schisandra chinensis was famously used in the Chinese traditional medicines as hepatoprotective, antioxidant, physical performance improvement and anticarcinogenic. This study was designed to determine the toxic fraction of Schisandra chinensis. In an acute toxicity test, the single dose of 200, 400, 800, 1200 and 1600 mg/kg were administered to the out-bred Mus musculus male mice. The oral LD50 value of the hexane extract in mice was 1420 mg/kg. Sedation, high respiration rate, urination, eye secretion, defecation and tremors were observed in mice between 6 to 72 hours. The first fraction of hexane extract with the least polar compound have the lowest IC50 and IC1o values (2.5 mg/ml and 0.75 mg/ml, respectively) followed by the second fraction (IC50 = 50 mg/ml, IC10 = 4.5 mg/ml). 2006 Thesis https://ir.uitm.edu.my/id/eprint/99088/ https://ir.uitm.edu.my/id/eprint/99088/1/99088.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Yan, Choo Chee
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Yan, Choo Chee
topic RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
Ab Rahman, Norul Izza
Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman
description Schisandra chinensis was famously used in the Chinese traditional medicines as hepatoprotective, antioxidant, physical performance improvement and anticarcinogenic. This study was designed to determine the toxic fraction of Schisandra chinensis. In an acute toxicity test, the single dose of 200, 400, 800, 1200 and 1600 mg/kg were administered to the out-bred Mus musculus male mice. The oral LD50 value of the hexane extract in mice was 1420 mg/kg. Sedation, high respiration rate, urination, eye secretion, defecation and tremors were observed in mice between 6 to 72 hours. The first fraction of hexane extract with the least polar compound have the lowest IC50 and IC1o values (2.5 mg/ml and 0.75 mg/ml, respectively) followed by the second fraction (IC50 = 50 mg/ml, IC10 = 4.5 mg/ml).
format Thesis
qualification_level Bachelor degree
author Ab Rahman, Norul Izza
author_facet Ab Rahman, Norul Izza
author_sort Ab Rahman, Norul Izza
title Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman
title_short Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman
title_full Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman
title_fullStr Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman
title_full_unstemmed Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman
title_sort toxicity evaluation of schisandra chinensis / norul izza ab rahman
granting_institution Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department Faculty of Pharmacy
publishDate 2006
url https://ir.uitm.edu.my/id/eprint/99088/1/99088.PDF
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