Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman
Schisandra chinensis was famously used in the Chinese traditional medicines as hepatoprotective, antioxidant, physical performance improvement and anticarcinogenic. This study was designed to determine the toxic fraction of Schisandra chinensis. In an acute toxicity test, the single dose of 200, 400...
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2006
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my-uitm-ir.990882024-07-24T03:39:32Z Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman 2006 Ab Rahman, Norul Izza RM Therapeutics. Pharmacology RS Pharmacy and materia medica Schisandra chinensis was famously used in the Chinese traditional medicines as hepatoprotective, antioxidant, physical performance improvement and anticarcinogenic. This study was designed to determine the toxic fraction of Schisandra chinensis. In an acute toxicity test, the single dose of 200, 400, 800, 1200 and 1600 mg/kg were administered to the out-bred Mus musculus male mice. The oral LD50 value of the hexane extract in mice was 1420 mg/kg. Sedation, high respiration rate, urination, eye secretion, defecation and tremors were observed in mice between 6 to 72 hours. The first fraction of hexane extract with the least polar compound have the lowest IC50 and IC1o values (2.5 mg/ml and 0.75 mg/ml, respectively) followed by the second fraction (IC50 = 50 mg/ml, IC10 = 4.5 mg/ml). 2006 Thesis https://ir.uitm.edu.my/id/eprint/99088/ https://ir.uitm.edu.my/id/eprint/99088/1/99088.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Yan, Choo Chee |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
Yan, Choo Chee |
| topic |
RM Therapeutics Pharmacology RS Pharmacy and materia medica |
| spellingShingle |
RM Therapeutics Pharmacology RS Pharmacy and materia medica Ab Rahman, Norul Izza Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman |
| description |
Schisandra chinensis was famously used in the Chinese traditional medicines as hepatoprotective, antioxidant, physical performance improvement and anticarcinogenic. This study was designed to determine the toxic fraction of Schisandra chinensis. In an acute toxicity test, the single dose of 200, 400, 800, 1200 and 1600 mg/kg were administered to the out-bred Mus musculus male mice. The oral LD50 value of the hexane extract in mice was 1420 mg/kg. Sedation, high respiration rate, urination, eye secretion, defecation and tremors were observed in mice between 6 to 72 hours. The first fraction of hexane extract with the least polar compound have the lowest IC50 and IC1o values (2.5 mg/ml and 0.75 mg/ml, respectively) followed by the second fraction (IC50 = 50 mg/ml, IC10 = 4.5 mg/ml). |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Ab Rahman, Norul Izza |
| author_facet |
Ab Rahman, Norul Izza |
| author_sort |
Ab Rahman, Norul Izza |
| title |
Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman |
| title_short |
Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman |
| title_full |
Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman |
| title_fullStr |
Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman |
| title_full_unstemmed |
Toxicity evaluation of schisandra chinensis / Norul Izza Ab Rahman |
| title_sort |
toxicity evaluation of schisandra chinensis / norul izza ab rahman |
| granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
| granting_department |
Faculty of Pharmacy |
| publishDate |
2006 |
| url |
https://ir.uitm.edu.my/id/eprint/99088/1/99088.PDF |
| _version_ |
1811768981229404160 |