Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan

The physical-chemical properties and compatibilities of several commonly used pharmaceutical excipients with ascorbic acid were evaluated using thermal method. Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ascorbic acid with some current...

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Main Author:	Mohd Sapuan, Hendrawati
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99090/1/99090.PDF
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id	my-uitm-ir.99090
record_format	uketd_dc
spelling	my-uitm-ir.990902024-07-24T03:39:26Z Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan 2006 Mohd Sapuan, Hendrawati RM Therapeutics. Pharmacology RS Pharmacy and materia medica The physical-chemical properties and compatibilities of several commonly used pharmaceutical excipients with ascorbic acid were evaluated using thermal method. Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ascorbic acid with some currently employed pharmaceutical excipients such as avicel, magnesium stearate and lactose. The influence of different storage temperature on the drug stability in binary mixture after one month was also evaluated. On the basis of DSC result, ascorbic acid was found to be compatible with lactose and PEG 4000. Some drug-excipient interaction was observed with avicel and magnesium stearate. Result shows that, decomposition of ascorbic acid in binary mixtures is higher as the storage temperature is increase except for mixture containing lactose. Thermogravimetry (TG) was of help in interpreting the DSC results. 2006 Thesis https://ir.uitm.edu.my/id/eprint/99090/ https://ir.uitm.edu.my/id/eprint/99090/1/99090.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sameni, Javad Khadem
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sameni, Javad Khadem
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Mohd Sapuan, Hendrawati Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan
description	The physical-chemical properties and compatibilities of several commonly used pharmaceutical excipients with ascorbic acid were evaluated using thermal method. Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ascorbic acid with some currently employed pharmaceutical excipients such as avicel, magnesium stearate and lactose. The influence of different storage temperature on the drug stability in binary mixture after one month was also evaluated. On the basis of DSC result, ascorbic acid was found to be compatible with lactose and PEG 4000. Some drug-excipient interaction was observed with avicel and magnesium stearate. Result shows that, decomposition of ascorbic acid in binary mixtures is higher as the storage temperature is increase except for mixture containing lactose. Thermogravimetry (TG) was of help in interpreting the DSC results.
format	Thesis
qualification_level	Bachelor degree
author	Mohd Sapuan, Hendrawati
author_facet	Mohd Sapuan, Hendrawati
author_sort	Mohd Sapuan, Hendrawati
title	Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan
title_short	Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan
title_full	Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan
title_fullStr	Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan
title_full_unstemmed	Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan
title_sort	thermal analysis of ascorbic acid and its compatibility with excipients by using dsc and tg/dtg methods / hendrawati mohd sapuan
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/99090/1/99090.PDF
_version_	1811768981759983616

Thermal analysis of ascorbic acid and its compatibility with excipients by using DSC and tg/dtg methods / Hendrawati Mohd Sapuan

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