Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim

The proposed paper describes the formation of clotrimazole loaded in a composite Hyaluronic acid (HA) microsphere by spray drying process. Clotrimazole, the lipophilic drug, was widely used as a broad spectrum antifungal agent all over the world. Its lipophilic properties limits its solubility in aq...

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Main Author:	Kasim, Azura
Format:	Thesis
Language:	English
Published:	2006
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99127/1/99127.PDF
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id	my-uitm-ir.99127
record_format	uketd_dc
spelling	my-uitm-ir.991272024-07-24T03:39:23Z Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim 2006 Kasim, Azura RM Therapeutics. Pharmacology RS Pharmacy and materia medica The proposed paper describes the formation of clotrimazole loaded in a composite Hyaluronic acid (HA) microsphere by spray drying process. Clotrimazole, the lipophilic drug, was widely used as a broad spectrum antifungal agent all over the world. Its lipophilic properties limits its solubility in aqueous phase, therefore, preparing microsphere with hydrophilic polymer will helps its solubility in this medium. In this study, clotrimazole incorporated with sodium hyaluronate microsphere was determined using UV-visible spectrophotometer at its maximal absorption of 2 l 5nm wavelength. Briefly, prior to UV detection, the microspheres were initially diluted in the miscible solvent, methanol:water (2: 1, v/v). The calibration graph was linear over the concentration range of l -9µg/ml. The correlation coefficient of the calibration curve was ?:0.99. The morphology, particle size, encapsulation efficiency and drug loading were also investigated. Study under analytical scanning electron microscopy revealed a smooth surface microsphere presenting a hole. The average size of drug loaded microsphere were 22.60-47.70µmeter and 41.00-57.90µmeter in diameter for microsphere produced from l lml/min and 3ml/min respectively, the encapsulation efficiency was 84.71% and drug loading was 33.98% for microsphere produced from 11 ml/min and 66.57% encapsulation efficiency and 74.29% for those produced from 3ml/min feed rate. Hence, clotrimazole loaded hyaluronic acid microsphere could be considered as a basic unit to develop new device for the treatment of fungal infection. 2006 Thesis https://ir.uitm.edu.my/id/eprint/99127/ https://ir.uitm.edu.my/id/eprint/99127/1/99127.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Ramli, Nor Amlizan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ramli, Nor Amlizan
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Kasim, Azura Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim
description	The proposed paper describes the formation of clotrimazole loaded in a composite Hyaluronic acid (HA) microsphere by spray drying process. Clotrimazole, the lipophilic drug, was widely used as a broad spectrum antifungal agent all over the world. Its lipophilic properties limits its solubility in aqueous phase, therefore, preparing microsphere with hydrophilic polymer will helps its solubility in this medium. In this study, clotrimazole incorporated with sodium hyaluronate microsphere was determined using UV-visible spectrophotometer at its maximal absorption of 2 l 5nm wavelength. Briefly, prior to UV detection, the microspheres were initially diluted in the miscible solvent, methanol:water (2: 1, v/v). The calibration graph was linear over the concentration range of l -9µg/ml. The correlation coefficient of the calibration curve was ?:0.99. The morphology, particle size, encapsulation efficiency and drug loading were also investigated. Study under analytical scanning electron microscopy revealed a smooth surface microsphere presenting a hole. The average size of drug loaded microsphere were 22.60-47.70µmeter and 41.00-57.90µmeter in diameter for microsphere produced from l lml/min and 3ml/min respectively, the encapsulation efficiency was 84.71% and drug loading was 33.98% for microsphere produced from 11 ml/min and 66.57% encapsulation efficiency and 74.29% for those produced from 3ml/min feed rate. Hence, clotrimazole loaded hyaluronic acid microsphere could be considered as a basic unit to develop new device for the treatment of fungal infection.
format	Thesis
qualification_level	Bachelor degree
author	Kasim, Azura
author_facet	Kasim, Azura
author_sort	Kasim, Azura
title	Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim
title_short	Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim
title_full	Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim
title_fullStr	Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim
title_full_unstemmed	Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim
title_sort	development of microsphere of polymer containing clotrimazole by spray drying process / azura kasim
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2006
url	https://ir.uitm.edu.my/id/eprint/99127/1/99127.PDF
_version_	1811768989299245056

Development of microsphere of polymer containing clotrimazole by spray drying process / Azura Kasim

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