Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang

The aim of this research project was to screen for anticonvulsant activity in endophytes isolated from Garcinia scortechinii (HAB10 R12). Locally known as 'pokok kandis', G. scortechinii is a small slender tree which is distributed throughout Malaysia and Southern Thailand. This plant has...

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Main Author:	Ajik @ Amboragang, Rizuan
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99575/1/99575.PDF
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id	my-uitm-ir.99575
record_format	uketd_dc
spelling	my-uitm-ir.995752024-08-02T10:19:42Z Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang 2007 Ajik @ Amboragang, Rizuan RM Therapeutics. Pharmacology RS Pharmacy and materia medica The aim of this research project was to screen for anticonvulsant activity in endophytes isolated from Garcinia scortechinii (HAB10 R12). Locally known as 'pokok kandis', G. scortechinii is a small slender tree which is distributed throughout Malaysia and Southern Thailand. This plant has been studied to have numerous bioactivities. The crude ethyl acetate extract was intraperitoneally injected (administered on three different acute doses which are 25 mg/kg, 50 mg/kg, 75 mg/kg and a chronic dose of 50mg/kg) IO minutes prior to the administration of picrotoxin (10 mg/kg), a known convulsant which antagonizes non-competitively the effect of y-aminobutyric acid (GABA). GABA is a known major inhibitory neurotransmitter in the central nervous system (CNS). The results of this research project showed a significant anticonvulsant property at a dose of 50 mg/kg administered either acutely or chronically. Thus, the results suggest the presence of anticonvulsant compounds in ethyl acetate extract of HAB10 R12. This finding can be a trigger to further study the anticonvulsant effect of the HAB IO RI 2 so that a new and better antiepileptic drug (AED) can be developed. The existing AEDs are commonly associated with dose-related, acute and chronic toxicities among patients with epilepsy which in tum deteriorates their quality of life. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99575/ https://ir.uitm.edu.my/id/eprint/99575/1/99575.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Venkataraman, B.V.
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Venkataraman, B.V.
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Ajik @ Amboragang, Rizuan Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang
description	The aim of this research project was to screen for anticonvulsant activity in endophytes isolated from Garcinia scortechinii (HAB10 R12). Locally known as 'pokok kandis', G. scortechinii is a small slender tree which is distributed throughout Malaysia and Southern Thailand. This plant has been studied to have numerous bioactivities. The crude ethyl acetate extract was intraperitoneally injected (administered on three different acute doses which are 25 mg/kg, 50 mg/kg, 75 mg/kg and a chronic dose of 50mg/kg) IO minutes prior to the administration of picrotoxin (10 mg/kg), a known convulsant which antagonizes non-competitively the effect of y-aminobutyric acid (GABA). GABA is a known major inhibitory neurotransmitter in the central nervous system (CNS). The results of this research project showed a significant anticonvulsant property at a dose of 50 mg/kg administered either acutely or chronically. Thus, the results suggest the presence of anticonvulsant compounds in ethyl acetate extract of HAB10 R12. This finding can be a trigger to further study the anticonvulsant effect of the HAB IO RI 2 so that a new and better antiepileptic drug (AED) can be developed. The existing AEDs are commonly associated with dose-related, acute and chronic toxicities among patients with epilepsy which in tum deteriorates their quality of life.
format	Thesis
qualification_level	Bachelor degree
author	Ajik @ Amboragang, Rizuan
author_facet	Ajik @ Amboragang, Rizuan
author_sort	Ajik @ Amboragang, Rizuan
title	Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang
title_short	Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang
title_full	Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang
title_fullStr	Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang
title_full_unstemmed	Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang
title_sort	screening for anticonvulsant activity of hab10 r12 / rizuan ajik @ amboragang
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99575/1/99575.PDF
_version_	1811769002448388096

Screening for anticonvulsant activity of HAB10 R12 / Rizuan Ajik @ Amboragang

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