Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat

The sub-acute toxicity of the aqueous extract of Eugenia polyantha (Myrtaceae) was studied in mice. In sub-acute toxicity studies, oral administration of 0.5 g/kg of Eugenia polyantha produced neither mortality nor changes in behaviour or any other physiological activities. No mortality was observed...

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Main Author:	Hamat, Noor Nazira
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99579/1/99579.PDF
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id	my-uitm-ir.99579
record_format	uketd_dc
spelling	my-uitm-ir.995792024-08-02T10:19:37Z Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat 2007 Hamat, Noor Nazira RM Therapeutics. Pharmacology RS Pharmacy and materia medica The sub-acute toxicity of the aqueous extract of Eugenia polyantha (Myrtaceae) was studied in mice. In sub-acute toxicity studies, oral administration of 0.5 g/kg of Eugenia polyantha produced neither mortality nor changes in behaviour or any other physiological activities. No mortality was observed when a dose of 0.5 g/kg/day of aqueous extract of Eugenia polyantha extract were administered orally for a period of 28 days. In the blood chemistry analysis, no significant changes occurred in creatinine, blood urea nitrogen (BUN), aspartate transaminase (AST), alanine transaminase (ALT), total billirrubin, cholesterol, low density lipoprotein (LDL), triglycerides, cholesterol, creatinine kinase, total prothrombin and uric acid. Hematological analysis showed no differences in any of the parameters examined: white blood cell count (WBC), red blood cell count (RBC), haemoglobin concentration, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), neutrophils, lymphocytes, monocytes, eosinophils, basophils and thrombin in either the control or treated group. There were no significant difference in TBARS values in lung, liver, heart and kidneys of the mice in both control and treated groups. There were no significant differences in the body weight and relative organ weights between controls and treated animals. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99579/ https://ir.uitm.edu.my/id/eprint/99579/1/99579.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Adam, Aishah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Adam, Aishah
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Hamat, Noor Nazira Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat
description	The sub-acute toxicity of the aqueous extract of Eugenia polyantha (Myrtaceae) was studied in mice. In sub-acute toxicity studies, oral administration of 0.5 g/kg of Eugenia polyantha produced neither mortality nor changes in behaviour or any other physiological activities. No mortality was observed when a dose of 0.5 g/kg/day of aqueous extract of Eugenia polyantha extract were administered orally for a period of 28 days. In the blood chemistry analysis, no significant changes occurred in creatinine, blood urea nitrogen (BUN), aspartate transaminase (AST), alanine transaminase (ALT), total billirrubin, cholesterol, low density lipoprotein (LDL), triglycerides, cholesterol, creatinine kinase, total prothrombin and uric acid. Hematological analysis showed no differences in any of the parameters examined: white blood cell count (WBC), red blood cell count (RBC), haemoglobin concentration, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), neutrophils, lymphocytes, monocytes, eosinophils, basophils and thrombin in either the control or treated group. There were no significant difference in TBARS values in lung, liver, heart and kidneys of the mice in both control and treated groups. There were no significant differences in the body weight and relative organ weights between controls and treated animals.
format	Thesis
qualification_level	Bachelor degree
author	Hamat, Noor Nazira
author_facet	Hamat, Noor Nazira
author_sort	Hamat, Noor Nazira
title	Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat
title_short	Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat
title_full	Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat
title_fullStr	Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat
title_full_unstemmed	Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat
title_sort	sub-acute toxicity of eugenia polyantha / noor nazira hamat
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99579/1/99579.PDF
_version_	1811769002954850304

Sub-acute toxicity of eugenia polyantha / Noor Nazira Hamat

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