Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal
The potential use of microwave irradiation as an approach for designing dissolution medium for poorly water soluble drugs was investigated. In order to make the drugs dissolve in the water, the microwave irradiation was used to modify the physicochemical properties of deionized water. Sulphanilamide...
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2007
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my-uitm-ir.995882024-08-02T04:07:57Z Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal 2007 Kamal, Mardhiyah RM Therapeutics. Pharmacology RS Pharmacy and materia medica The potential use of microwave irradiation as an approach for designing dissolution medium for poorly water soluble drugs was investigated. In order to make the drugs dissolve in the water, the microwave irradiation was used to modify the physicochemical properties of deionized water. Sulphanilamide and sulphathiazole were selected as the model poorly water soluble drugs. The deionized water was subjected to microwave irradiation at 80 W for 37.5 min and at 300 W for 10 min. The profiles of drug dissolution, drug solubility, media pH, temperature, conductivity and mobility were determined. In order to increase the dissolution rate of low aqueous solubility drugs, deionized water molecules were made more mobile through subjecting them to treatment by microwave irradiation. The energy absorbed by the water molecules can break the bond interaction between the molecules and thus make the water molecules more accessible to interact with poor water-soluble drug and aid to disperse and dissolve the drug molecules in the dissolution medium. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99588/ https://ir.uitm.edu.my/id/eprint/99588/1/99588.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Wui, Wong Tin |
institution |
Universiti Teknologi MARA |
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UiTM Institutional Repository |
language |
English |
advisor |
Wui, Wong Tin |
topic |
RM Therapeutics Pharmacology RS Pharmacy and materia medica |
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RM Therapeutics Pharmacology RS Pharmacy and materia medica Kamal, Mardhiyah Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal |
description |
The potential use of microwave irradiation as an approach for designing dissolution medium for poorly water soluble drugs was investigated. In order to make the drugs dissolve in the water, the microwave irradiation was used to modify the physicochemical properties of deionized water. Sulphanilamide and sulphathiazole were selected as the model poorly water soluble drugs. The deionized water was subjected to microwave irradiation at 80 W for 37.5 min and at 300 W for 10 min. The profiles of drug dissolution, drug solubility, media pH, temperature, conductivity and mobility were determined. In order to increase the dissolution rate of low aqueous solubility drugs, deionized water molecules were made more mobile through subjecting them to treatment by microwave irradiation. The energy absorbed by the water molecules can break the bond interaction between the molecules and thus make the water molecules more accessible to interact with poor water-soluble drug and aid to disperse and dissolve the drug molecules in the dissolution medium. |
format |
Thesis |
qualification_level |
Bachelor degree |
author |
Kamal, Mardhiyah |
author_facet |
Kamal, Mardhiyah |
author_sort |
Kamal, Mardhiyah |
title |
Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal |
title_short |
Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal |
title_full |
Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal |
title_fullStr |
Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal |
title_full_unstemmed |
Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal |
title_sort |
influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / mardhiyah kamal |
granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
granting_department |
Faculty of Pharmacy |
publishDate |
2007 |
url |
https://ir.uitm.edu.my/id/eprint/99588/1/99588.PDF |
_version_ |
1811769003961483264 |