Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal

The potential use of microwave irradiation as an approach for designing dissolution medium for poorly water soluble drugs was investigated. In order to make the drugs dissolve in the water, the microwave irradiation was used to modify the physicochemical properties of deionized water. Sulphanilamide...

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Main Author: Kamal, Mardhiyah
Format: Thesis
Language:English
Published: 2007
Subjects:
Online Access:https://ir.uitm.edu.my/id/eprint/99588/1/99588.PDF
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spelling my-uitm-ir.995882024-08-02T04:07:57Z Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal 2007 Kamal, Mardhiyah RM Therapeutics. Pharmacology RS Pharmacy and materia medica The potential use of microwave irradiation as an approach for designing dissolution medium for poorly water soluble drugs was investigated. In order to make the drugs dissolve in the water, the microwave irradiation was used to modify the physicochemical properties of deionized water. Sulphanilamide and sulphathiazole were selected as the model poorly water soluble drugs. The deionized water was subjected to microwave irradiation at 80 W for 37.5 min and at 300 W for 10 min. The profiles of drug dissolution, drug solubility, media pH, temperature, conductivity and mobility were determined. In order to increase the dissolution rate of low aqueous solubility drugs, deionized water molecules were made more mobile through subjecting them to treatment by microwave irradiation. The energy absorbed by the water molecules can break the bond interaction between the molecules and thus make the water molecules more accessible to interact with poor water-soluble drug and aid to disperse and dissolve the drug molecules in the dissolution medium. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99588/ https://ir.uitm.edu.my/id/eprint/99588/1/99588.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Wui, Wong Tin
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Wui, Wong Tin
topic RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
Kamal, Mardhiyah
Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal
description The potential use of microwave irradiation as an approach for designing dissolution medium for poorly water soluble drugs was investigated. In order to make the drugs dissolve in the water, the microwave irradiation was used to modify the physicochemical properties of deionized water. Sulphanilamide and sulphathiazole were selected as the model poorly water soluble drugs. The deionized water was subjected to microwave irradiation at 80 W for 37.5 min and at 300 W for 10 min. The profiles of drug dissolution, drug solubility, media pH, temperature, conductivity and mobility were determined. In order to increase the dissolution rate of low aqueous solubility drugs, deionized water molecules were made more mobile through subjecting them to treatment by microwave irradiation. The energy absorbed by the water molecules can break the bond interaction between the molecules and thus make the water molecules more accessible to interact with poor water-soluble drug and aid to disperse and dissolve the drug molecules in the dissolution medium.
format Thesis
qualification_level Bachelor degree
author Kamal, Mardhiyah
author_facet Kamal, Mardhiyah
author_sort Kamal, Mardhiyah
title Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal
title_short Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal
title_full Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal
title_fullStr Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal
title_full_unstemmed Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal
title_sort influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / mardhiyah kamal
granting_institution Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department Faculty of Pharmacy
publishDate 2007
url https://ir.uitm.edu.my/id/eprint/99588/1/99588.PDF
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