Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff

Stilbenes are known to have important biological actrvrties and various therapeutic properties. Because of the minute amount in plants and the increasing demand for it, stilbene analogues are synthesized in the laboratory by using Heck reaction. Heck reaction is palladium-catalyzed C-C coupling betw...

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Main Author:	Md Yusoff, Noorsidah
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99633/1/99633.PDF
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id	my-uitm-ir.99633
record_format	uketd_dc
spelling	my-uitm-ir.996332024-08-01T22:46:33Z Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff 2007 Md Yusoff, Noorsidah RM Therapeutics. Pharmacology RS Pharmacy and materia medica Stilbenes are known to have important biological actrvrties and various therapeutic properties. Because of the minute amount in plants and the increasing demand for it, stilbene analogues are synthesized in the laboratory by using Heck reaction. Heck reaction is palladium-catalyzed C-C coupling between aryl halides and activated alkenes in the presence of a base. Due to high-cost of palladium, nickel (II) acetate tetrahydrate which was relatively very cheap compared to palladium was used as a catalyst in this research. As claimed by other researchers, nickel has a higher activity in Heck reaction although palladium was known to be the most active catalyst. Therefore, this research was aimed to synthesize stilbene analogue by using Heck reaction and also to observe the efficacy of nickel (11) acetate tetrahydrate in terms of the amount and the temperature that are required to be used for the reaction. This research was carried out in two established reactions. The first reaction was to produce protected 4-iodophenol, 4-iodoanisole by using iodomethane. The successfully synthesized 4-iodoanisole was not used in the next step due to small amount and hence, was not enough to be consumed in the next reaction, the Heck reaction. The second reaction was to produce the stilbene analogue, trans-4, 12-dimethoxystilbene by using commercially available 4- iodoanisole and 4-methoxystyrene. However, due to some reasons the stilbene analogue was not able to be synthesized. Instead, an unknown compound which was not able to be identified has been synthesized in small amount. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99633/ https://ir.uitm.edu.my/id/eprint/99633/1/99633.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Abdul Wahab, Ibtisam
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Abdul Wahab, Ibtisam
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Md Yusoff, Noorsidah Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff
description	Stilbenes are known to have important biological actrvrties and various therapeutic properties. Because of the minute amount in plants and the increasing demand for it, stilbene analogues are synthesized in the laboratory by using Heck reaction. Heck reaction is palladium-catalyzed C-C coupling between aryl halides and activated alkenes in the presence of a base. Due to high-cost of palladium, nickel (II) acetate tetrahydrate which was relatively very cheap compared to palladium was used as a catalyst in this research. As claimed by other researchers, nickel has a higher activity in Heck reaction although palladium was known to be the most active catalyst. Therefore, this research was aimed to synthesize stilbene analogue by using Heck reaction and also to observe the efficacy of nickel (11) acetate tetrahydrate in terms of the amount and the temperature that are required to be used for the reaction. This research was carried out in two established reactions. The first reaction was to produce protected 4-iodophenol, 4-iodoanisole by using iodomethane. The successfully synthesized 4-iodoanisole was not used in the next step due to small amount and hence, was not enough to be consumed in the next reaction, the Heck reaction. The second reaction was to produce the stilbene analogue, trans-4, 12-dimethoxystilbene by using commercially available 4- iodoanisole and 4-methoxystyrene. However, due to some reasons the stilbene analogue was not able to be synthesized. Instead, an unknown compound which was not able to be identified has been synthesized in small amount.
format	Thesis
qualification_level	Bachelor degree
author	Md Yusoff, Noorsidah
author_facet	Md Yusoff, Noorsidah
author_sort	Md Yusoff, Noorsidah
title	Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff
title_short	Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff
title_full	Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff
title_fullStr	Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff
title_full_unstemmed	Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff
title_sort	nickel (ii) acetate tetrahydrate and triphenylphosphine in heck coupling / noorsidah md yusoff
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99633/1/99633.PDF
_version_	1811769011137937408

Nickel (II) acetate tetrahydrate and triphenylphosphine in heck coupling / Noorsidah Md Yusoff

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