Synthesis and analytical studies of phenacetin / Azlan Ahmad

Phenacetin, an analgesic, can be synthesized in 2 ways; either Williamson Ether Synthesis or Amide Synthesis as the final process. This is due to the para substitution between ether and amide group on benzene ring. For this project, the starting material is the phenol. This phenol will be protonated...

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Main Author:	Ahmad, Azlan
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99634/1/99634.PDF
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id	my-uitm-ir.99634
record_format	uketd_dc
spelling	my-uitm-ir.996342024-08-01T22:46:30Z Synthesis and analytical studies of phenacetin / Azlan Ahmad 2007 Ahmad, Azlan RM Therapeutics. Pharmacology RS Pharmacy and materia medica Phenacetin, an analgesic, can be synthesized in 2 ways; either Williamson Ether Synthesis or Amide Synthesis as the final process. This is due to the para substitution between ether and amide group on benzene ring. For this project, the starting material is the phenol. This phenol will be protonated follow by nitration by electrophile aromatic substitution to yield nitrophenol. At this stage, the chemist can decide to follow Williamson Ether Synthesis first or amide synthesis. But in this projecct, the compound will transform first into nitrophenetole by Williamson ether synthesis, then reduced to nitro group and finally undergo amide synthesis to yield phenacetin. The final compound will be analyzed by Thin-Layer Chromatography, Nuclear Magnetic Resonance, UV visible spectrometry and simple capillary melting point. Phenacetin is brown crystalline compound and has melting point in the range of 134-136 C. Although it is important to get the final product, however, the purpose for this project been done is to obtain and practice with the laboratory works. This purpose leads the student to adapt with the environment of chemistry. All the skills need to be integrated to accomplish the aim of this project. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99634/ https://ir.uitm.edu.my/id/eprint/99634/1/99634.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mat Jusoh, Mohd Zulkefeli
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mat Jusoh, Mohd Zulkefeli
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Ahmad, Azlan Synthesis and analytical studies of phenacetin / Azlan Ahmad
description	Phenacetin, an analgesic, can be synthesized in 2 ways; either Williamson Ether Synthesis or Amide Synthesis as the final process. This is due to the para substitution between ether and amide group on benzene ring. For this project, the starting material is the phenol. This phenol will be protonated follow by nitration by electrophile aromatic substitution to yield nitrophenol. At this stage, the chemist can decide to follow Williamson Ether Synthesis first or amide synthesis. But in this projecct, the compound will transform first into nitrophenetole by Williamson ether synthesis, then reduced to nitro group and finally undergo amide synthesis to yield phenacetin. The final compound will be analyzed by Thin-Layer Chromatography, Nuclear Magnetic Resonance, UV visible spectrometry and simple capillary melting point. Phenacetin is brown crystalline compound and has melting point in the range of 134-136 C. Although it is important to get the final product, however, the purpose for this project been done is to obtain and practice with the laboratory works. This purpose leads the student to adapt with the environment of chemistry. All the skills need to be integrated to accomplish the aim of this project.
format	Thesis
qualification_level	Bachelor degree
author	Ahmad, Azlan
author_facet	Ahmad, Azlan
author_sort	Ahmad, Azlan
title	Synthesis and analytical studies of phenacetin / Azlan Ahmad
title_short	Synthesis and analytical studies of phenacetin / Azlan Ahmad
title_full	Synthesis and analytical studies of phenacetin / Azlan Ahmad
title_fullStr	Synthesis and analytical studies of phenacetin / Azlan Ahmad
title_full_unstemmed	Synthesis and analytical studies of phenacetin / Azlan Ahmad
title_sort	synthesis and analytical studies of phenacetin / azlan ahmad
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99634/1/99634.PDF
_version_	1811769011407421440

Synthesis and analytical studies of phenacetin / Azlan Ahmad

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