In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili
Epilepsy is a chronic and progressive brain disorder which is characterized by occurrence of periodic and unpredictable seizures attack which may be originating from both or only partial hemisphere of the brain. It can affect anyone regardless to age, social, racial, sex or geographical border. As i...
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my-uitm-ir.996352024-08-01T22:46:25Z In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili 2007 Sapili, Siti Norhayati RM Therapeutics. Pharmacology RS Pharmacy and materia medica Epilepsy is a chronic and progressive brain disorder which is characterized by occurrence of periodic and unpredictable seizures attack which may be originating from both or only partial hemisphere of the brain. It can affect anyone regardless to age, social, racial, sex or geographical border. As in developing countries where modem drug therapy is hard to be obtained, most of the people still rely on traditional healer for any ailments they faced and even in some countries traditional healers are the person given the authority to treat epilepsy. There are a large variety of synthetic antiepileptic drugs available but since most of the therapy require prolong duration of treatment and the common practice of polypharmacy in prescribing antiepileptic drugs which increases the possibility of toxicity development, there are called to run a research on developing a better and safer medicines from potential medicinal plant. The fungi extract used in this study was isolated from local medicinal plant and recent study revealed its cytotoxicity properties against cancer cells. Upon exposure to acute doses of this fungi extract, the onset of seizure attack, peak time and death time of the mice which injected with picrotoxin were delayed. The picrotoxin was used to induce the convulsion attack and administered intraperitoneally. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99635/ https://ir.uitm.edu.my/id/eprint/99635/1/99635.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Abdul Majeed, Abu Bakar |
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Universiti Teknologi MARA |
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English |
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Abdul Majeed, Abu Bakar |
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RM Therapeutics Pharmacology RS Pharmacy and materia medica |
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RM Therapeutics Pharmacology RS Pharmacy and materia medica Sapili, Siti Norhayati In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili |
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Epilepsy is a chronic and progressive brain disorder which is characterized by occurrence of periodic and unpredictable seizures attack which may be originating from both or only partial hemisphere of the brain. It can affect anyone regardless to age, social, racial, sex or geographical border. As in developing countries where modem drug therapy is hard to be obtained, most of the people still rely on traditional healer for any ailments they faced and even in some countries traditional healers are the person given the authority to treat epilepsy. There are a large variety of synthetic antiepileptic drugs available but since most of the therapy require prolong duration of treatment and the common practice of polypharmacy in prescribing antiepileptic drugs which increases the possibility of toxicity development, there are called to run a research on developing a better and safer medicines from potential medicinal plant. The fungi extract used in this study was isolated from local medicinal plant and recent study revealed its cytotoxicity properties against cancer cells. Upon exposure to acute doses of this fungi extract, the onset of seizure attack, peak time and death time of the mice which injected with picrotoxin were delayed. The picrotoxin was used to induce the convulsion attack and administered intraperitoneally. |
format |
Thesis |
qualification_level |
Bachelor degree |
author |
Sapili, Siti Norhayati |
author_facet |
Sapili, Siti Norhayati |
author_sort |
Sapili, Siti Norhayati |
title |
In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili |
title_short |
In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili |
title_full |
In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili |
title_fullStr |
In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili |
title_full_unstemmed |
In-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / Siti Norhayati Sapili |
title_sort |
in-vivo study on the anticonvulsant activity of the endophytic fungi extract from local plant / siti norhayati sapili |
granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
granting_department |
Faculty of Pharmacy |
publishDate |
2007 |
url |
https://ir.uitm.edu.my/id/eprint/99635/1/99635.PDF |
_version_ |
1811769011663273984 |