Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit

Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit

Phosphine ligands have been used as ligands in Heck reaction to produce stilbene. Nevertheless different ligands used in a reaction may produce different yields and effect of desired compound. Therefore, the aim of the research was to study the effect of different phosphine ligands in Heck coupling...

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Main Author: Wan Yeit, Wan Aziyani Yazmin
Format: Thesis
Language:English
Published: 2007
Subjects:
RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
Online Access:https://ir.uitm.edu.my/id/eprint/99686/1/99686.PDF
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spelling my-uitm-ir.996862024-08-02T10:19:26Z Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit 2007 Wan Yeit, Wan Aziyani Yazmin RM Therapeutics. Pharmacology RS Pharmacy and materia medica Phosphine ligands have been used as ligands in Heck reaction to produce stilbene. Nevertheless different ligands used in a reaction may produce different yields and effect of desired compound. Therefore, the aim of the research was to study the effect of different phosphine ligands in Heck coupling reaction. Heck reactions were done by using 4 different ligands, tri-o-tolylphosphine, tetraphenylphosphonium chloride, methyl triphenylphoshponium iodide and tetrakis (tripheynlphosphonium) palladium with para­ iodophenol and para-chlorostyrene as the starting materials. The yields of the desired compound are 33.85%, 70.29%, 6.51 % and 11.43% respectively. The products in each reaction were analyzed using TLC and extracted using ethyl acetate and hexane. Purification of the reaction products was done by using column chromatography. The desired compound was sent for NMR analysis for structure characterization. The spectra were recorded using 1H-NMR spectrometer in order to elucidate the structure of the compound. IR absorption was also used to analyze the structure characterization. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99686/ https://ir.uitm.edu.my/id/eprint/99686/1/99686.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Feroz, Fareeda
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Feroz, Fareeda
topic RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics
Pharmacology
RS Pharmacy and materia medica
Wan Yeit, Wan Aziyani Yazmin
Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit
description Phosphine ligands have been used as ligands in Heck reaction to produce stilbene. Nevertheless different ligands used in a reaction may produce different yields and effect of desired compound. Therefore, the aim of the research was to study the effect of different phosphine ligands in Heck coupling reaction. Heck reactions were done by using 4 different ligands, tri-o-tolylphosphine, tetraphenylphosphonium chloride, methyl triphenylphoshponium iodide and tetrakis (tripheynlphosphonium) palladium with para­ iodophenol and para-chlorostyrene as the starting materials. The yields of the desired compound are 33.85%, 70.29%, 6.51 % and 11.43% respectively. The products in each reaction were analyzed using TLC and extracted using ethyl acetate and hexane. Purification of the reaction products was done by using column chromatography. The desired compound was sent for NMR analysis for structure characterization. The spectra were recorded using 1H-NMR spectrometer in order to elucidate the structure of the compound. IR absorption was also used to analyze the structure characterization.
format Thesis
qualification_level Bachelor degree
author Wan Yeit, Wan Aziyani Yazmin
author_facet Wan Yeit, Wan Aziyani Yazmin
author_sort Wan Yeit, Wan Aziyani Yazmin
title Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit
title_short Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit
title_full Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit
title_fullStr Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit
title_full_unstemmed Phosphine ligands in heck coupling reaction / Wan Aziyani Yazmin Wan Yeit
title_sort phosphine ligands in heck coupling reaction / wan aziyani yazmin wan yeit
granting_institution Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department Faculty of Pharmacy
publishDate 2007
url https://ir.uitm.edu.my/id/eprint/99686/1/99686.PDF
_version_ 1811769019069366272

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