Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji

Cancer cells are abnormal cells that rapidly and excessively grow beyond their normal cell growth. From the total deaths worldwide, 13 percent were caused by cancer in 2005. The main types of cancers that lead to total death worldwide are; lung, stomach, liver, colon, and breast cancer. Breast cance...

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Main Author:	Mat Noji, Hajar
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99864/1/99864.PDF
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id	my-uitm-ir.99864
record_format	uketd_dc
spelling	my-uitm-ir.998642024-08-06T18:15:37Z Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji 2007 Mat Noji, Hajar RM Therapeutics. Pharmacology RS Pharmacy and materia medica Cancer cells are abnormal cells that rapidly and excessively grow beyond their normal cell growth. From the total deaths worldwide, 13 percent were caused by cancer in 2005. The main types of cancers that lead to total death worldwide are; lung, stomach, liver, colon, and breast cancer. Breast cancer is the most common form of cancer affecting women in Malaysia while colon cancer is one of the most common malignancies in the world. Cancers can be treated by surgery, radiotherapy and chemotherapy. Approximately 50% of cancer patients receive chemotherapy. Currently, these anti cancer drugs have some limitations; low selectivity and specificity, producing toxic effects and development of multi-drug resistance in patients. To date, anticancer drugs from natural sources are widely studied because these drugs may be potent towards cancer cells and less toxic which may exhibit better therapeutic outcome as compared to existing anticancer drugs. Endophytes are microorganisms that live symbiotically in healthy tissues of living plants. The first and most significant anticancer agent discovered was paclitaxel. It is widely used in the treatment against breast cancer. Due to high demand of new natural anti-cancer agent, this research is developed to investigate the cytotoxic properties of local endophytic fungi. The crude extracts of endophytic fungal that have been used in this research include the extract of HAB2R1, HAB13R21, and HAB15L10. Interestingly, HAB15L10 appeared to be effective towards colon and breast cancer cells. The average IC50 value of HAB15L10 was 0.35µg/ml. This extract should be further studied due to its beneficial effects towards colon and breast cancer cells. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99864/ https://ir.uitm.edu.my/id/eprint/99864/1/99864.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Ramasamy, Kalavathy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ramasamy, Kalavathy
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Mat Noji, Hajar Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji
description	Cancer cells are abnormal cells that rapidly and excessively grow beyond their normal cell growth. From the total deaths worldwide, 13 percent were caused by cancer in 2005. The main types of cancers that lead to total death worldwide are; lung, stomach, liver, colon, and breast cancer. Breast cancer is the most common form of cancer affecting women in Malaysia while colon cancer is one of the most common malignancies in the world. Cancers can be treated by surgery, radiotherapy and chemotherapy. Approximately 50% of cancer patients receive chemotherapy. Currently, these anti cancer drugs have some limitations; low selectivity and specificity, producing toxic effects and development of multi-drug resistance in patients. To date, anticancer drugs from natural sources are widely studied because these drugs may be potent towards cancer cells and less toxic which may exhibit better therapeutic outcome as compared to existing anticancer drugs. Endophytes are microorganisms that live symbiotically in healthy tissues of living plants. The first and most significant anticancer agent discovered was paclitaxel. It is widely used in the treatment against breast cancer. Due to high demand of new natural anti-cancer agent, this research is developed to investigate the cytotoxic properties of local endophytic fungi. The crude extracts of endophytic fungal that have been used in this research include the extract of HAB2R1, HAB13R21, and HAB15L10. Interestingly, HAB15L10 appeared to be effective towards colon and breast cancer cells. The average IC50 value of HAB15L10 was 0.35µg/ml. This extract should be further studied due to its beneficial effects towards colon and breast cancer cells.
format	Thesis
qualification_level	Bachelor degree
author	Mat Noji, Hajar
author_facet	Mat Noji, Hajar
author_sort	Mat Noji, Hajar
title	Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji
title_short	Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji
title_full	Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji
title_fullStr	Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji
title_full_unstemmed	Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji
title_sort	cytotoxic activity of endophytic fungal extracts hab2r1, hab13r21, and hab15l10 against breast and colon cancer cell lines / hajar mat noji
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99864/1/99864.PDF
_version_	1811769039650816000

Cytotoxic activity of endophytic fungal extracts HAB2R1, HAB13R21, and HAB15L10 against breast and colon cancer cell lines / Hajar Mat Noji

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