Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy

The main objective of this study is to synthesize a macrocyclic compound, 1,4,7,10-tetra azacyclododecane ( cyclen). There are several techniques involved in order to synthesize this compound. Although in this experiment, only one method was choosen from several methods that are able to synthesize...

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Main Author:	Mohd Khairy, Hasryn Azzuar
Format:	Thesis
Language:	English
Published:	2007
Subjects:	QD Chemistry RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99867/1/99867.PDF
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id	my-uitm-ir.99867
record_format	uketd_dc
spelling	my-uitm-ir.998672024-08-06T18:15:32Z Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy 2007 Mohd Khairy, Hasryn Azzuar QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica The main objective of this study is to synthesize a macrocyclic compound, 1,4,7,10-tetra azacyclododecane ( cyclen). There are several techniques involved in order to synthesize this compound. Although in this experiment, only one method was choosen from several methods that are able to synthesize this compound. This experiment used Diethylenetriamine (DT) and Diethanolamine (DE) as starting material. The Diethylenetriamine and Diethanolamine are tosylated first by using para-toluene benzyl chloride or called Tosyl chloride (TsCl) with addition of triethylamine as a base and dichloromethane as a solvent. Diethylenetriamine preparation will yield N-Tosyl as a product and Diethanolamine will yield 0-Tosyl as a product. Both of these products then coupled to yield the compound called cyclen that are very useful for the molecular study purposes. The already-made cyclen product from the factory made or commercially is available, but it is quite expensive, so that this experiment done to produce cyclen by ownself for the further purposes. Thin Layer Chromatography (TLC) is used for all of the chemical analysis and identification. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99867/ https://ir.uitm.edu.my/id/eprint/99867/1/99867.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mat Jusoh, Mohd Zulkefeli
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mat Jusoh, Mohd Zulkefeli
topic	QD Chemistry QD Chemistry RS Pharmacy and materia medica
spellingShingle	QD Chemistry QD Chemistry RS Pharmacy and materia medica Mohd Khairy, Hasryn Azzuar Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy
description	The main objective of this study is to synthesize a macrocyclic compound, 1,4,7,10-tetra azacyclododecane ( cyclen). There are several techniques involved in order to synthesize this compound. Although in this experiment, only one method was choosen from several methods that are able to synthesize this compound. This experiment used Diethylenetriamine (DT) and Diethanolamine (DE) as starting material. The Diethylenetriamine and Diethanolamine are tosylated first by using para-toluene benzyl chloride or called Tosyl chloride (TsCl) with addition of triethylamine as a base and dichloromethane as a solvent. Diethylenetriamine preparation will yield N-Tosyl as a product and Diethanolamine will yield 0-Tosyl as a product. Both of these products then coupled to yield the compound called cyclen that are very useful for the molecular study purposes. The already-made cyclen product from the factory made or commercially is available, but it is quite expensive, so that this experiment done to produce cyclen by ownself for the further purposes. Thin Layer Chromatography (TLC) is used for all of the chemical analysis and identification.
format	Thesis
qualification_level	Bachelor degree
author	Mohd Khairy, Hasryn Azzuar
author_facet	Mohd Khairy, Hasryn Azzuar
author_sort	Mohd Khairy, Hasryn Azzuar
title	Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy
title_short	Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy
title_full	Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy
title_fullStr	Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy
title_full_unstemmed	Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy
title_sort	synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / hasryn azzuar mohd khairy
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99867/1/99867.PDF
_version_	1811769040153083904

Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy

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