Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar

The effects of various receptor antagonists on the antinociceptive activity of the Bauhinia purpurea leaves' aqueous extract (BPAE) were examined using the mouse abdominal constriction test. Crude dried BPAE was prepared in the doses of 300, 500 and 1000 mg/kg and administered subcutaneously 30...

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Main Author:	Anuar, Khairiyah
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99875/1/99875.PDF
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id	my-uitm-ir.99875
record_format	uketd_dc
spelling	my-uitm-ir.998752024-08-06T09:51:03Z Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar 2007 Anuar, Khairiyah RM Therapeutics. Pharmacology RS Pharmacy and materia medica The effects of various receptor antagonists on the antinociceptive activity of the Bauhinia purpurea leaves' aqueous extract (BPAE) were examined using the mouse abdominal constriction test. Crude dried BPAE was prepared in the doses of 300, 500 and 1000 mg/kg and administered subcutaneously 30 min prior to the test. From the antinociceptive profile obtained, all doses of BPAE exhibited significant (p< 0.05) antinociceptive activity with the 300 mg/kg BPAE producing an activity that is equivalent in strength when compared to the 150 mg/kg ASA. Based on the profile, the 500 mg/kg BP AE was chosen for the next study involving the various receptor antagonists. The mice were pretreated subcutaneously with different types of antagonists for 10 min followed by the 500 mg/kg BPAE administration and 30 min later subjected to the test. Based on the results obtained, naloxone (3 and 10 mg/kg), haloperidol ( 1 mg/kg), yohimbine (5 mg/kg) and reserpine (2 mg/kg) significantly reversed the 500 mg/kg BPAE antinociceptive activity. In conclusion, the BPAE antinociceptive activity is suggested to be involved in modulation of opiod, dopaminergic, a-adrenergic and monoaminergic receptor systems. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99875/ https://ir.uitm.edu.my/id/eprint/99875/1/99875.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Zakaria, Zainul Amiruddin
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Zakaria, Zainul Amiruddin
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Anuar, Khairiyah Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar
description	The effects of various receptor antagonists on the antinociceptive activity of the Bauhinia purpurea leaves' aqueous extract (BPAE) were examined using the mouse abdominal constriction test. Crude dried BPAE was prepared in the doses of 300, 500 and 1000 mg/kg and administered subcutaneously 30 min prior to the test. From the antinociceptive profile obtained, all doses of BPAE exhibited significant (p< 0.05) antinociceptive activity with the 300 mg/kg BPAE producing an activity that is equivalent in strength when compared to the 150 mg/kg ASA. Based on the profile, the 500 mg/kg BP AE was chosen for the next study involving the various receptor antagonists. The mice were pretreated subcutaneously with different types of antagonists for 10 min followed by the 500 mg/kg BPAE administration and 30 min later subjected to the test. Based on the results obtained, naloxone (3 and 10 mg/kg), haloperidol ( 1 mg/kg), yohimbine (5 mg/kg) and reserpine (2 mg/kg) significantly reversed the 500 mg/kg BPAE antinociceptive activity. In conclusion, the BPAE antinociceptive activity is suggested to be involved in modulation of opiod, dopaminergic, a-adrenergic and monoaminergic receptor systems.
format	Thesis
qualification_level	Bachelor degree
author	Anuar, Khairiyah
author_facet	Anuar, Khairiyah
author_sort	Anuar, Khairiyah
title	Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar
title_short	Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar
title_full	Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar
title_fullStr	Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar
title_full_unstemmed	Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar
title_sort	effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / khairiyah anuar
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99875/1/99875.PDF
_version_	1811769041409277952

Effects of vario us receptor antagonists on the aqueous extract of bauhinia purpurea peripheral antinociceptive activity in mice / Khairiyah Anuar

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