Study on the preparation of PLGA-based microparticles / Fauziah Ismail

The purpose of the research is to study the preparation of drug delivery system using biodegradable polymer. The advantage of biodegradable polymer over other drug delivery system is that they are absorbable by the body thus leaving no trace. The material used in preparing the microparticulate syste...

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Main Author:	Ismail, Fauziah
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99880/1/99880.PDF
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id	my-uitm-ir.99880
record_format	uketd_dc
spelling	my-uitm-ir.998802024-08-06T18:01:01Z Study on the preparation of PLGA-based microparticles / Fauziah Ismail 2007 Ismail, Fauziah RM Therapeutics. Pharmacology RS Pharmacy and materia medica The purpose of the research is to study the preparation of drug delivery system using biodegradable polymer. The advantage of biodegradable polymer over other drug delivery system is that they are absorbable by the body thus leaving no trace. The material used in preparing the microparticulate system was PLGA or poly (lactic-co-glycolic) acid. PLGA-based microparticle was prepared using emulsion solvent extraction technique. The technique involves two different phases; organic phase and aqueous phase. The organic phase contains of dichloromethane (as solvent) and PLGA (a polymer). Meanwhile, aqueous phase contains distilled water and polyvinyl alcohol (as a stabilizing agent). In the study, we were focusing on the different parameters that affect the formation of microparticles. Three different parameters were considered; homogenizing speed, stabilizer concentration and temperature. The samples were prepared and analyzed using optical microscope, particle size analyzers and scanning electron microscope. It was determined that the particles size and size distribution were strongly correlated to the following parameters; homogenizing speed, stabilizer concentration and temperature. Surface morphology was strongly affected by temperature. The others two parameters doesn't significantly influence the surface morphology of microparticles. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99880/ https://ir.uitm.edu.my/id/eprint/99880/1/99880.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sameni, Javad Khadeem
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sameni, Javad Khadeem
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Ismail, Fauziah Study on the preparation of PLGA-based microparticles / Fauziah Ismail
description	The purpose of the research is to study the preparation of drug delivery system using biodegradable polymer. The advantage of biodegradable polymer over other drug delivery system is that they are absorbable by the body thus leaving no trace. The material used in preparing the microparticulate system was PLGA or poly (lactic-co-glycolic) acid. PLGA-based microparticle was prepared using emulsion solvent extraction technique. The technique involves two different phases; organic phase and aqueous phase. The organic phase contains of dichloromethane (as solvent) and PLGA (a polymer). Meanwhile, aqueous phase contains distilled water and polyvinyl alcohol (as a stabilizing agent). In the study, we were focusing on the different parameters that affect the formation of microparticles. Three different parameters were considered; homogenizing speed, stabilizer concentration and temperature. The samples were prepared and analyzed using optical microscope, particle size analyzers and scanning electron microscope. It was determined that the particles size and size distribution were strongly correlated to the following parameters; homogenizing speed, stabilizer concentration and temperature. Surface morphology was strongly affected by temperature. The others two parameters doesn't significantly influence the surface morphology of microparticles.
format	Thesis
qualification_level	Bachelor degree
author	Ismail, Fauziah
author_facet	Ismail, Fauziah
author_sort	Ismail, Fauziah
title	Study on the preparation of PLGA-based microparticles / Fauziah Ismail
title_short	Study on the preparation of PLGA-based microparticles / Fauziah Ismail
title_full	Study on the preparation of PLGA-based microparticles / Fauziah Ismail
title_fullStr	Study on the preparation of PLGA-based microparticles / Fauziah Ismail
title_full_unstemmed	Study on the preparation of PLGA-based microparticles / Fauziah Ismail
title_sort	study on the preparation of plga-based microparticles / fauziah ismail
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99880/1/99880.PDF
_version_	1811769042160058368

Study on the preparation of PLGA-based microparticles / Fauziah Ismail

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