Development of a PCR method for detection of UGTJAJ polymorphism / Khairul Muhaimin Othman

Irinotecan is a camptothecin analog with potent antitumor activity resulting from the inhibition of topoisomerase. Dose-limiting toxicity of irinotecan includes severe leukopenia, neutropenia and diarrhea. Genetic polymorphisms of UDP­ glucuronosyltransferase (UGT) lAl, a key metabolizing enzyme of...

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Bibliographic Details
Main Author: Othman, Khairul Muhaimin
Format: Thesis
Language:English
Published: 2007
Subjects:
Online Access:https://ir.uitm.edu.my/id/eprint/99883/1/99883.PDF
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