Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman

This research aims at investigating the effectiveness of nickel (II) acetate as a catalyst in the Heck reaction. Eight different conditions have been utilized in order to accomplish this research study. Each of these conditions was applied to synthesize the same stilbene. The commercially available...

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Main Author:	Nik Abdul Rahman, Nik Najibah
Format:	Thesis
Language:	English
Published:	2007
Subjects:	QD Chemistry RS Pharmacy and materia medica TP Chemical technology
Online Access:	https://ir.uitm.edu.my/id/eprint/99885/1/99885.PDF
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id	my-uitm-ir.99885
record_format	uketd_dc
spelling	my-uitm-ir.998852024-08-06T17:50:23Z Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman 2007 Nik Abdul Rahman, Nik Najibah QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology This research aims at investigating the effectiveness of nickel (II) acetate as a catalyst in the Heck reaction. Eight different conditions have been utilized in order to accomplish this research study. Each of these conditions was applied to synthesize the same stilbene. The commercially available 4-iodoanisole and 4-methoxystyrene were coupled together under the Heck reaction by using these conditions in attempt to synthesize 4, 12-dimethoxystilbene. As the result, utilizing nickel (II) acetate as a catalyst in the presence of tetraphenylphosphonium chloride as a ligand able to produce 1.07% yield only, while in the presence of tri-p-tolylphosphine, tri-o-tolylphosphine as a ligand, and cesium carbonate as a base was not able to produce any yield respectively. By utilizing palladium chloride as a catalyst in the presence of the same conditions, the desired stilbene able to be produced with the yield of 40% (with tetraphenylphosphonium chloride), 20.05% (with tri-p-tolylphosphine), 4.11 % (with tri-o-tolylphosphine), and 5% (with cesium carbonate). TLC, 1H NMR and FT-IR characterization were used to confirm the desired product. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99885/ https://ir.uitm.edu.my/id/eprint/99885/1/99885.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Feroz, Fareeda
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Feroz, Fareeda
topic	QD Chemistry QD Chemistry RS Pharmacy and materia medica TP Chemical technology
spellingShingle	QD Chemistry QD Chemistry RS Pharmacy and materia medica TP Chemical technology Nik Abdul Rahman, Nik Najibah Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman
description	This research aims at investigating the effectiveness of nickel (II) acetate as a catalyst in the Heck reaction. Eight different conditions have been utilized in order to accomplish this research study. Each of these conditions was applied to synthesize the same stilbene. The commercially available 4-iodoanisole and 4-methoxystyrene were coupled together under the Heck reaction by using these conditions in attempt to synthesize 4, 12-dimethoxystilbene. As the result, utilizing nickel (II) acetate as a catalyst in the presence of tetraphenylphosphonium chloride as a ligand able to produce 1.07% yield only, while in the presence of tri-p-tolylphosphine, tri-o-tolylphosphine as a ligand, and cesium carbonate as a base was not able to produce any yield respectively. By utilizing palladium chloride as a catalyst in the presence of the same conditions, the desired stilbene able to be produced with the yield of 40% (with tetraphenylphosphonium chloride), 20.05% (with tri-p-tolylphosphine), 4.11 % (with tri-o-tolylphosphine), and 5% (with cesium carbonate). TLC, 1H NMR and FT-IR characterization were used to confirm the desired product.
format	Thesis
qualification_level	Bachelor degree
author	Nik Abdul Rahman, Nik Najibah
author_facet	Nik Abdul Rahman, Nik Najibah
author_sort	Nik Abdul Rahman, Nik Najibah
title	Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman
title_short	Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman
title_full	Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman
title_fullStr	Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman
title_full_unstemmed	Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman
title_sort	nickel (ii) acetate in heck coupling / nik najibah nik abdul rahman
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99885/1/99885.PDF
_version_	1811769043427786752

Nickel (II) acetate in heck coupling / Nik Najibah Nik Abdul Rahman

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