Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah

The purpose of incorporation PLGA (Poly lactic-co-glycolic acid) polymer is to prolong the action NSAIDs of choice (ibuprofen and aspirin) preparations in order to diminish the number of consumption for its analgesic effects and thus facilitate their usage. The purpose of this study was to investiga...

Full description

Saved in:

Bibliographic Details
Main Author:	Rosli Ahmad Abdullah, Nur Ain
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99951/1/99951.PDF
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.99951
record_format	uketd_dc
spelling	my-uitm-ir.999512024-08-07T14:18:36Z Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah 2007 Rosli Ahmad Abdullah, Nur Ain RM Therapeutics. Pharmacology RS Pharmacy and materia medica The purpose of incorporation PLGA (Poly lactic-co-glycolic acid) polymer is to prolong the action NSAIDs of choice (ibuprofen and aspirin) preparations in order to diminish the number of consumption for its analgesic effects and thus facilitate their usage. The purpose of this study was to investigate the effect of solution temperature, PY A concentration and PLGA: drug ratio on drug loading and drug entrapment efficiency. Other than that, this study also was conducted to investigate the difference in morphology of hydrophilic drug and hydrophobic drug entrap in microparticles and determine the thermal properties of microparticles with drug. The drug loading of ibuprofen and aspirin in the samples was determined through calculation of drug content percentage and drug entrapment percentage calculation. The concentration of ibuprofen and aspirin was crosscheck with UV analysis using UV spectrophotometer. The surface morphology of the samples was determined using scanning electron microscope (SEM). Thermal analysis of the PLGA microparticles and PLGA drug loaded microparticles were determined by using differential scanning calorimetry (DSC). Drug loading results show high drug loading with high ratio of PLGA used, lower solution temperature and high polyvinyl alcohol percentage as the surfactant in the microparticles preparation. Glass transition temperature of PLGA is around 52.3°C and incorporation of drug in the PLGA microparticles shifts the glass transition temperature to the right or higher temperature. Morphology of the PLGA ibuprofen loaded show spherical shape but with much lower size than PLGA drug free microparticles. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99951/ https://ir.uitm.edu.my/id/eprint/99951/1/99951.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sameni, Javad Khadem
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sameni, Javad Khadem
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Rosli Ahmad Abdullah, Nur Ain Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah
description	The purpose of incorporation PLGA (Poly lactic-co-glycolic acid) polymer is to prolong the action NSAIDs of choice (ibuprofen and aspirin) preparations in order to diminish the number of consumption for its analgesic effects and thus facilitate their usage. The purpose of this study was to investigate the effect of solution temperature, PY A concentration and PLGA: drug ratio on drug loading and drug entrapment efficiency. Other than that, this study also was conducted to investigate the difference in morphology of hydrophilic drug and hydrophobic drug entrap in microparticles and determine the thermal properties of microparticles with drug. The drug loading of ibuprofen and aspirin in the samples was determined through calculation of drug content percentage and drug entrapment percentage calculation. The concentration of ibuprofen and aspirin was crosscheck with UV analysis using UV spectrophotometer. The surface morphology of the samples was determined using scanning electron microscope (SEM). Thermal analysis of the PLGA microparticles and PLGA drug loaded microparticles were determined by using differential scanning calorimetry (DSC). Drug loading results show high drug loading with high ratio of PLGA used, lower solution temperature and high polyvinyl alcohol percentage as the surfactant in the microparticles preparation. Glass transition temperature of PLGA is around 52.3°C and incorporation of drug in the PLGA microparticles shifts the glass transition temperature to the right or higher temperature. Morphology of the PLGA ibuprofen loaded show spherical shape but with much lower size than PLGA drug free microparticles.
format	Thesis
qualification_level	Bachelor degree
author	Rosli Ahmad Abdullah, Nur Ain
author_facet	Rosli Ahmad Abdullah, Nur Ain
author_sort	Rosli Ahmad Abdullah, Nur Ain
title	Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah
title_short	Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah
title_full	Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah
title_fullStr	Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah
title_full_unstemmed	Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah
title_sort	study on various parameters on the ibuprofen and aspirin loading with plga microparticles / nur ain rosli ahmad abdullah
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99951/1/99951.PDF
_version_	1811769065788669952

Study on various parameters on the ibuprofen and aspirin loading with PLGA microparticles / Nur Ain Rosli Ahmad Abdullah

Similar Items