Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan

The purpose of using PLGA polymer in this experiment is to prolong the action of ibuprofen. Thus the number of administration can be reduced and this may increase patient compliance due to decrease number of pills or capsules to be taken per day. This study is designed to investigate the rate of ibu...

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Main Author:	Hassan, Halmy
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RM Therapeutics Pharmacology RS Pharmacy and materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/99965/1/99965.PDF
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id	my-uitm-ir.99965
record_format	uketd_dc
spelling	my-uitm-ir.999652024-08-07T14:05:28Z Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan 2007 Hassan, Halmy RM Therapeutics. Pharmacology RS Pharmacy and materia medica The purpose of using PLGA polymer in this experiment is to prolong the action of ibuprofen. Thus the number of administration can be reduced and this may increase patient compliance due to decrease number of pills or capsules to be taken per day. This study is designed to investigate the rate of ibuprofen release from the drug, the mechanism associated with the drug release from the PLGA, the effect of pH and temperature to ibuprofen release from the microparticles and how different ratio of polymer to the drug can affect the morphology of the microparticles. Concentration of ibuprofen release from the polymer was measured by using UV-Vis spectrophotometer and the surface morphology was determined by using scanning electron microscope (SEM). In vitro release shows that, at physiological temperature, ibuprofen released at faster rate compared at 25° C . At higher pH, about 100% of drug being released while at gastric pH 90% of drug are being released. Different ratio of polymer to the drug concentration does not affect the surface morphology of the microparticles. 2007 Thesis https://ir.uitm.edu.my/id/eprint/99965/ https://ir.uitm.edu.my/id/eprint/99965/1/99965.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Zakaria, Zainul
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Zakaria, Zainul
topic	RM Therapeutics Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics Pharmacology RS Pharmacy and materia medica Hassan, Halmy Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan
description	The purpose of using PLGA polymer in this experiment is to prolong the action of ibuprofen. Thus the number of administration can be reduced and this may increase patient compliance due to decrease number of pills or capsules to be taken per day. This study is designed to investigate the rate of ibuprofen release from the drug, the mechanism associated with the drug release from the PLGA, the effect of pH and temperature to ibuprofen release from the microparticles and how different ratio of polymer to the drug can affect the morphology of the microparticles. Concentration of ibuprofen release from the polymer was measured by using UV-Vis spectrophotometer and the surface morphology was determined by using scanning electron microscope (SEM). In vitro release shows that, at physiological temperature, ibuprofen released at faster rate compared at 25° C . At higher pH, about 100% of drug being released while at gastric pH 90% of drug are being released. Different ratio of polymer to the drug concentration does not affect the surface morphology of the microparticles.
format	Thesis
qualification_level	Bachelor degree
author	Hassan, Halmy
author_facet	Hassan, Halmy
author_sort	Hassan, Halmy
title	Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan
title_short	Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan
title_full	Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan
title_fullStr	Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan
title_full_unstemmed	Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan
title_sort	effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / halmy hassan
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/99965/1/99965.PDF
_version_	1811769067299667968

Effect of various antagonists on the peripheral antinociceptive activity of aqueous extract of melastoma malabathricum in mice / Halmy Hassan

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