Incorporating energy generation process in environmental assessment of a biopharmaceutical process

Biopharmaceutical industries consistently applied Water for Injection (WFI) as a solvent during their production stage. Generally, water is considered as non-hazardous material, but in the pharmaceutical industries the involved treatments to produce WET typically consumes a large amount of energy. T...

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Main Author:	Auni Hamimi, Idris
Format:	Thesis
Language:	English
Published:	2015
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/16931/19/Incorporating%20energy%20generation%20process%20in%20environmental%20assessment%20of%20a%20biopharmaceutical%20process.pdf
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spelling	my-ump-ir.169312021-12-01T00:13:44Z Incorporating energy generation process in environmental assessment of a biopharmaceutical process 2015-12 Auni Hamimi, Idris TP Chemical technology Biopharmaceutical industries consistently applied Water for Injection (WFI) as a solvent during their production stage. Generally, water is considered as non-hazardous material, but in the pharmaceutical industries the involved treatments to produce WET typically consumes a large amount of energy. This energy usually comes from the use of utility steam as well as electricity to heat the water as part of the purification process. Consequently, generation of utility steam and electricity needed to produce WFI releases gas pollutants and directly affecting the environment. However, such potential environmental impact (PEI), which is associated to the demand of WFI in a biopharmaceutical process, is typically not included in the environmental assessment of the process as water is considered benign. Therefore, this work aims to estimate the PET value from WFT and pure steam generation using a simple algorithm which is modified from Waste Reduction (WAR) Algorithm. The PEI is estimated based on the gas pollutants emitted from the energy generation process, which is in this case, the electricity and utility steam. In order to determine the energy needed in WET and pure steam generation, their generation system was modelled and simulated in SuperPro Designer®. WFI is typically produced in Multiple Effect Distillation (MED) system or Vapour Compression Distillation (VCD) system and meanwhile pure steam is produced in pure steam generator (PSG). A hypothetical large-scale of monoclonal antibody (MAb) production is used as a case study to demonstrate the environmental impact assessment using WAR Algorithm inclusive of PET from WFI and pure steam demand during manufacturing process. From the case study, it can be concluded that the WET generation, regardless of using MED or VCD, occupied the largest percentage of energy consumption. The PET shows a major contribution to the total PET value, particularly in global warming potential. The hotspot based on the highest WET consumption is Protein A chromatography. This equipment is used in the downstream processing step to purify the target product. As biopharmaceutical process needs a large amount of WET in the process, therefore it is important to include PET from WFI as part of the environmental assessment. This result is essentially useful as a tool for decision-making in order to create a more sustainable process. 2015-12 Thesis http://umpir.ump.edu.my/id/eprint/16931/ http://umpir.ump.edu.my/id/eprint/16931/19/Incorporating%20energy%20generation%20process%20in%20environmental%20assessment%20of%20a%20biopharmaceutical%20process.pdf pdf en public masters Universiti Malaysia Pahang Faculty of Chemical & Natural Resources Engineering
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
collection	UMPSA Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Auni Hamimi, Idris Incorporating energy generation process in environmental assessment of a biopharmaceutical process
description	Biopharmaceutical industries consistently applied Water for Injection (WFI) as a solvent during their production stage. Generally, water is considered as non-hazardous material, but in the pharmaceutical industries the involved treatments to produce WET typically consumes a large amount of energy. This energy usually comes from the use of utility steam as well as electricity to heat the water as part of the purification process. Consequently, generation of utility steam and electricity needed to produce WFI releases gas pollutants and directly affecting the environment. However, such potential environmental impact (PEI), which is associated to the demand of WFI in a biopharmaceutical process, is typically not included in the environmental assessment of the process as water is considered benign. Therefore, this work aims to estimate the PET value from WFT and pure steam generation using a simple algorithm which is modified from Waste Reduction (WAR) Algorithm. The PEI is estimated based on the gas pollutants emitted from the energy generation process, which is in this case, the electricity and utility steam. In order to determine the energy needed in WET and pure steam generation, their generation system was modelled and simulated in SuperPro Designer®. WFI is typically produced in Multiple Effect Distillation (MED) system or Vapour Compression Distillation (VCD) system and meanwhile pure steam is produced in pure steam generator (PSG). A hypothetical large-scale of monoclonal antibody (MAb) production is used as a case study to demonstrate the environmental impact assessment using WAR Algorithm inclusive of PET from WFI and pure steam demand during manufacturing process. From the case study, it can be concluded that the WET generation, regardless of using MED or VCD, occupied the largest percentage of energy consumption. The PET shows a major contribution to the total PET value, particularly in global warming potential. The hotspot based on the highest WET consumption is Protein A chromatography. This equipment is used in the downstream processing step to purify the target product. As biopharmaceutical process needs a large amount of WET in the process, therefore it is important to include PET from WFI as part of the environmental assessment. This result is essentially useful as a tool for decision-making in order to create a more sustainable process.
format	Thesis
qualification_level	Master's degree
author	Auni Hamimi, Idris
author_facet	Auni Hamimi, Idris
author_sort	Auni Hamimi, Idris
title	Incorporating energy generation process in environmental assessment of a biopharmaceutical process
title_short	Incorporating energy generation process in environmental assessment of a biopharmaceutical process
title_full	Incorporating energy generation process in environmental assessment of a biopharmaceutical process
title_fullStr	Incorporating energy generation process in environmental assessment of a biopharmaceutical process
title_full_unstemmed	Incorporating energy generation process in environmental assessment of a biopharmaceutical process
title_sort	incorporating energy generation process in environmental assessment of a biopharmaceutical process
granting_institution	Universiti Malaysia Pahang
granting_department	Faculty of Chemical & Natural Resources Engineering
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/16931/19/Incorporating%20energy%20generation%20process%20in%20environmental%20assessment%20of%20a%20biopharmaceutical%20process.pdf
_version_	1783732016978591744

Incorporating energy generation process in environmental assessment of a biopharmaceutical process

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