Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation

Carbamazepine (CBZ) has a problem of slow rate of absorption when administered orally in which a larger dose of the drug is needed in order to be effective in treating patients. Recently, the carbamazepine-saccharin (CBZ-SAC) co-crystal has been reported to improve the solubility through solution cr...

Full description

Saved in:

Bibliographic Details
Main Author:	Engku Nadia, Engku Mat Nasir
Format:	Thesis
Language:	English
Published:	2022
Subjects:	T Technology (General) TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/36851/1/ir.Crystal%20size%20distribution%20characterisation%20of%20Carbamazepine-saccharin%20co-crystal.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-ump-ir.36851
record_format	uketd_dc
spelling	my-ump-ir.368512023-09-14T07:00:49Z Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation 2022-07 Engku Nadia, Engku Mat Nasir T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Carbamazepine (CBZ) has a problem of slow rate of absorption when administered orally in which a larger dose of the drug is needed in order to be effective in treating patients. Recently, the carbamazepine-saccharin (CBZ-SAC) co-crystal has been reported to improve the solubility through solution crystallisation method. The solubility of CBZ-SAC co-crystal is mostly influenced by factors such as surface area, phase transformation, crystal size distribution (CSD), and fluid dynamics. In order to obtained the desired crystal properties, the operating parameters should be controlled in the metastable zone width (MSZW) throughout the crystallisation process. There is limited report on the CSD of CBZ-SAC co-crystal therefore, the crystal size distribution of carbamazepine-saccharin co-crystal in batch cooling crystallisation was studied. Polythermal method of cooling crystallisation was conducted to study the MSZW and CSD of CBZ-SAC co-crystal by testing with different mole ratio of SAC to CBZ, different cooling rates and different stirring speeds at various concentration of CBZ. The CBZ-SAC co-crystal were characterised by using particle size analyser, differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transforms infrared (FTIR) and optical microscopy. The findings found that the concentration increases the crystallisation temperature, Tcryst and dissolution temperature, Tdiss also increased. The MSZW is higher for the higher CBZ concentration and stirring speed. The nucleation order, m increases as the mole ratio of SAC/CBZ increases with decreasing MSZW. The value of nucleation kinetic constant, k is found to increase with the increasing concentration for low mol ratio. Meanwhile, for slow cooling of CSD study of CBZ-SAC co-crystal, the broad CSD and larger mean crystal size is found at higher concentration of CBZ with low stirring speed. The narrow CSD and smaller mean crystal size is observed at higher stirring speed for all mole ratio and cooling rate. The CSD study of CBZ-SAC co-crystal for fast cooling also shows broad CSD with large mean crystal size and narrow CSD with small mean crystal size at higher CBZ concentration for different mole ratio and cooling rate. The characterisation analysis of DSC, XRPD and FTIR revealed that the produced solid is CBZ- SAC co-crystal Form I. Optical microscopy showed that the CBZ-SAC co-crystal Form I have the morphology of plate-like crystal. The findings obtained in the study are useful in the crystal processing, handling and storage especially in pharmaceutical industries. 2022-07 Thesis http://umpir.ump.edu.my/id/eprint/36851/ http://umpir.ump.edu.my/id/eprint/36851/1/ir.Crystal%20size%20distribution%20characterisation%20of%20Carbamazepine-saccharin%20co-crystal.pdf pdf en public masters Universiti Malaysia Pahang Faculty of Chemical and Process Engineering Technology Syarifah, Abd Rahim
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
collection	UMPSA Institutional Repository
language	English
advisor	Syarifah, Abd Rahim
topic	T Technology (General) T Technology (General) TP Chemical technology
spellingShingle	T Technology (General) T Technology (General) TP Chemical technology Engku Nadia, Engku Mat Nasir Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation
description	Carbamazepine (CBZ) has a problem of slow rate of absorption when administered orally in which a larger dose of the drug is needed in order to be effective in treating patients. Recently, the carbamazepine-saccharin (CBZ-SAC) co-crystal has been reported to improve the solubility through solution crystallisation method. The solubility of CBZ-SAC co-crystal is mostly influenced by factors such as surface area, phase transformation, crystal size distribution (CSD), and fluid dynamics. In order to obtained the desired crystal properties, the operating parameters should be controlled in the metastable zone width (MSZW) throughout the crystallisation process. There is limited report on the CSD of CBZ-SAC co-crystal therefore, the crystal size distribution of carbamazepine-saccharin co-crystal in batch cooling crystallisation was studied. Polythermal method of cooling crystallisation was conducted to study the MSZW and CSD of CBZ-SAC co-crystal by testing with different mole ratio of SAC to CBZ, different cooling rates and different stirring speeds at various concentration of CBZ. The CBZ-SAC co-crystal were characterised by using particle size analyser, differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transforms infrared (FTIR) and optical microscopy. The findings found that the concentration increases the crystallisation temperature, Tcryst and dissolution temperature, Tdiss also increased. The MSZW is higher for the higher CBZ concentration and stirring speed. The nucleation order, m increases as the mole ratio of SAC/CBZ increases with decreasing MSZW. The value of nucleation kinetic constant, k is found to increase with the increasing concentration for low mol ratio. Meanwhile, for slow cooling of CSD study of CBZ-SAC co-crystal, the broad CSD and larger mean crystal size is found at higher concentration of CBZ with low stirring speed. The narrow CSD and smaller mean crystal size is observed at higher stirring speed for all mole ratio and cooling rate. The CSD study of CBZ-SAC co-crystal for fast cooling also shows broad CSD with large mean crystal size and narrow CSD with small mean crystal size at higher CBZ concentration for different mole ratio and cooling rate. The characterisation analysis of DSC, XRPD and FTIR revealed that the produced solid is CBZ- SAC co-crystal Form I. Optical microscopy showed that the CBZ-SAC co-crystal Form I have the morphology of plate-like crystal. The findings obtained in the study are useful in the crystal processing, handling and storage especially in pharmaceutical industries.
format	Thesis
qualification_level	Master's degree
author	Engku Nadia, Engku Mat Nasir
author_facet	Engku Nadia, Engku Mat Nasir
author_sort	Engku Nadia, Engku Mat Nasir
title	Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation
title_short	Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation
title_full	Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation
title_fullStr	Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation
title_full_unstemmed	Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation
title_sort	crystal size distribution characterisation of carbamazepine-saccharin co-crystal in batch cooling crystallisation
granting_institution	Universiti Malaysia Pahang
granting_department	Faculty of Chemical and Process Engineering Technology
publishDate	2022
url	http://umpir.ump.edu.my/id/eprint/36851/1/ir.Crystal%20size%20distribution%20characterisation%20of%20Carbamazepine-saccharin%20co-crystal.pdf
_version_	1783732256728154112

Crystal size distribution characterisation of Carbamazepine-saccharin co-crystal in batch cooling crystallisation

Similar Items