Enhanced segment particle swarm optimization for large-scale kinetic parameter estimation of escherichia coli network model
The development of a large-scale metabolic model of Escherichia coli (E. coli) is very crucial to identify the potential solution of industrially viable productions. However, the large-scale kinetic parameters estimation using optimization algorithms is still not applied to the main metabolic pathwa...
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| Format: | Thesis |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/39571/1/ir.Enhanced%20segment%20particle%20swarm%20optimization%20for%20large-scale%20kinetic%20parameter%20estimation.pdf |
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| Summary: | The development of a large-scale metabolic model of Escherichia coli (E. coli) is very crucial to identify the potential solution of industrially viable productions. However, the large-scale kinetic parameters estimation using optimization algorithms is still not applied to the main metabolic pathway of the E. coli model, and they’re a lack of accuracy result been reported for current parameters estimation using this approach. Thus, this research aimed to estimate large-scale kinetic parameters of the main metabolic pathway of the E. coli model. In this regard, a Local Sensitivity Analysis, Segment Particle Swarm Optimization (Se-PSO) algorithm, and the Enhanced Segment Particle Swarm Optimization (ESe-PSO) algorithm was adapted and proposed to estimate the parameters. Initially, PSO algorithm was adapted to find the globally optimal result based on unorganized particle movement in the search space toward the optimal solution. This development then introduces the Se-PSO algorithm in which the particles are segmented to find a local optimal solution at the beginning and later sought by the PSO algorithm. Additionally, the study proposed an Enhance Se-PSO algorithm to improve the linear value of inertia weight |
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