Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model

Type 2 diabetes has reached epidemic proportions worldwide. The resulting increase in chronic and costly diabetes related complications has potentially catastrophic implications for healthcare systems, and economics and societies as a whole. One of the key pathological factors leading to type 2 diab...

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Main Author:	Ummu Kulthum, Jamaludin
Format:	Thesis
Language:	English
Published:	2013
Subjects:	RM Therapeutics Pharmacology
Online Access:	http://umpir.ump.edu.my/id/eprint/7733/1/UMMU_KULTHUM_JAMALUDIN.PDF
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id	my-ump-ir.7733
record_format	uketd_dc
spelling	my-ump-ir.77332021-08-18T05:07:07Z Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model 2013 Ummu Kulthum, Jamaludin RM Therapeutics. Pharmacology Type 2 diabetes has reached epidemic proportions worldwide. The resulting increase in chronic and costly diabetes related complications has potentially catastrophic implications for healthcare systems, and economics and societies as a whole. One of the key pathological factors leading to type 2 diabetes is insulin resistance (IR), which is the reduced or impaired ability of the body to make use of available insulin to maintain safe glucose concentrations in the bloodstream. It is essential to understand the physiology of glucose and insulin when investigating the underlying factors contributing to chronic diseases such as diabetes and cardiovascular disease. For many years, clinicians and researchers have been working to develop and use model-based methods to increase understanding and aid therapeutic decision support. However, the majority of practicable tests cannot yield more than basic metrics that allow only a threshold-based assessment of the underlying disorder. This thesis gives an overview on several dynamic model-based methodologies with different clinical applications in assessing glycaemia via measuring effects of treatment or medication on insulin sensitivity. Other tests are clinically focused, designed to screen populations and diagnose or detect the risk of developing diabetes. Thus, it is very important to observe sensitivity metrics in various clinical and research settings. 2013 Thesis http://umpir.ump.edu.my/id/eprint/7733/ http://umpir.ump.edu.my/id/eprint/7733/1/UMMU_KULTHUM_JAMALUDIN.PDF application/pdf en public phd doctoral University of Canterbury, Christchurch, New Zealand University of Canterbury
institution	Universiti Malaysia Pahang Al-Sultan Abdullah
collection	UMPSA Institutional Repository
language	English
topic	RM Therapeutics Pharmacology
spellingShingle	RM Therapeutics Pharmacology Ummu Kulthum, Jamaludin Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
description	Type 2 diabetes has reached epidemic proportions worldwide. The resulting increase in chronic and costly diabetes related complications has potentially catastrophic implications for healthcare systems, and economics and societies as a whole. One of the key pathological factors leading to type 2 diabetes is insulin resistance (IR), which is the reduced or impaired ability of the body to make use of available insulin to maintain safe glucose concentrations in the bloodstream. It is essential to understand the physiology of glucose and insulin when investigating the underlying factors contributing to chronic diseases such as diabetes and cardiovascular disease. For many years, clinicians and researchers have been working to develop and use model-based methods to increase understanding and aid therapeutic decision support. However, the majority of practicable tests cannot yield more than basic metrics that allow only a threshold-based assessment of the underlying disorder. This thesis gives an overview on several dynamic model-based methodologies with different clinical applications in assessing glycaemia via measuring effects of treatment or medication on insulin sensitivity. Other tests are clinically focused, designed to screen populations and diagnose or detect the risk of developing diabetes. Thus, it is very important to observe sensitivity metrics in various clinical and research settings.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ummu Kulthum, Jamaludin
author_facet	Ummu Kulthum, Jamaludin
author_sort	Ummu Kulthum, Jamaludin
title	Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
title_short	Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
title_full	Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
title_fullStr	Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
title_full_unstemmed	Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
title_sort	developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model
granting_institution	University of Canterbury, Christchurch, New Zealand
granting_department	University of Canterbury
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/7733/1/UMMU_KULTHUM_JAMALUDIN.PDF
_version_	1783731943112704000

Developing and validating a new comprehensive glucose-insulin pharmacokinetics and pharmacodynamics model

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