Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic
Three novel concepts have been emerged in breast cancer biology: the role of cancer stem cells (CSC) in tumor initiation, and the involvement of an epithelial to mesenchymal transition (EMT) in the invasiveness and metastasis of cancer cells, along with the telomerase role in_ keeping the CSC immort...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/37487/1/24%20PAGES.pdf https://eprints.ums.edu.my/id/eprint/37487/2/FULLTEXT.pdf |
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| Summary: | Three novel concepts have been emerged in breast cancer biology: the role of cancer stem cells (CSC) in tumor initiation, and the involvement of an epithelial to mesenchymal transition (EMT) in the invasiveness and metastasis of cancer cells, along with the telomerase role in_ keeping the CSC immortal, and avoidino senescence. CSC are a small subpopulation of cells within tumors that initiate the tumor, telomerase is the intracellular enzyme responsible for the elongation of chromosomal telomer during each cell division, while EMT is the loss of epithelial differentiation and gained the mesenchymal phenotype. |
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