SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS
Ferrocene-indole is a series of organometallic molecules that consist of a ferrocene moiety directly or indirectly attached to an indole core at any possible position of substitution. A series of seven new ferrocene-indole molecules was synthesised, designed and their cytotoxicity were tested aga...
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| Format: | Thesis |
| Language: | English |
| Online Access: | http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/1/Abstract.pdf http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/2/Synthesis%2c%20characterization%2c%20cytotoxic%20activity%20evaluation%20and%20structure-activity%20relationship%20study%20of%20new%20ferrocene-indole%20derivatives%20as%20potential%20anticancer%20agents.pdf |
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| Summary: | Ferrocene-indole is a series of organometallic molecules that consist of a ferrocene
moiety directly or indirectly attached to an indole core at any possible position of
substitution. A series of seven new ferrocene-indole molecules was synthesised,
designed and their cytotoxicity were tested against cancer cell lines. The study
concludes that ferrocene-indole with indole substituted at position 2 and 7 are more
active in cytotoxicity compared to the others in the series. The employed synthesis
method was a resemblance of Steglich Esterification, with EDC·HCl acted as
coupling agent and DMAP as catalyst. A precursor molecule,
ferrocenephenylenediamine was synthesised through EDC coupling. In addition, a
series of ferrocenephenyldiamide-indole was synthesised using the mentioned
precursor, with all six possible indoles substituted by the precursor. Characterisation
of the compounds were accomplished by Nuclear Magnetic Resonance (NMR),
Fourier-Transform Infrared Spectroscopy (FT-IR), CHN Elemental Analysis and
Mass Spectroscopy (MS). Meanwhile, MTS Assay was chosen as a biological
evaluation of the six ferrocene-indole hybrids. |
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