SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS
Ferrocene-indole is a series of organometallic molecules that consist of a ferrocene moiety directly or indirectly attached to an indole core at any possible position of substitution. A series of seven new ferrocene-indole molecules was synthesised, designed and their cytotoxicity were tested aga...
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| Online Access: | http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/1/Abstract.pdf http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/2/Synthesis%2c%20characterization%2c%20cytotoxic%20activity%20evaluation%20and%20structure-activity%20relationship%20study%20of%20new%20ferrocene-indole%20derivatives%20as%20potential%20anticancer%20agents.pdf |
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my-umt-ir.-164232022-02-15T03:15:57Z SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS LIEW KEN MIN Ferrocene-indole is a series of organometallic molecules that consist of a ferrocene moiety directly or indirectly attached to an indole core at any possible position of substitution. A series of seven new ferrocene-indole molecules was synthesised, designed and their cytotoxicity were tested against cancer cell lines. The study concludes that ferrocene-indole with indole substituted at position 2 and 7 are more active in cytotoxicity compared to the others in the series. The employed synthesis method was a resemblance of Steglich Esterification, with EDC·HCl acted as coupling agent and DMAP as catalyst. A precursor molecule, ferrocenephenylenediamine was synthesised through EDC coupling. In addition, a series of ferrocenephenyldiamide-indole was synthesised using the mentioned precursor, with all six possible indoles substituted by the precursor. Characterisation of the compounds were accomplished by Nuclear Magnetic Resonance (NMR), Fourier-Transform Infrared Spectroscopy (FT-IR), CHN Elemental Analysis and Mass Spectroscopy (MS). Meanwhile, MTS Assay was chosen as a biological evaluation of the six ferrocene-indole hybrids. UNIVERSITI MALAYSIA TERENGGANU 2020 Thesis en http://umt-ir.umt.edu.my:8080/handle/123456789/16423 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/1/Abstract.pdf bb5c7890519ab186cb137ccca7372a64 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/2/Synthesis%2c%20characterization%2c%20cytotoxic%20activity%20evaluation%20and%20structure-activity%20relationship%20study%20of%20new%20ferrocene-indole%20derivatives%20as%20potential%20anticancer%20agents.pdf 9847368ba06f61abafafa60a42068415 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 |
| institution |
Universiti Malaysia Terengganu |
| collection |
UMT Repository System |
| language |
English |
| description |
Ferrocene-indole is a series of organometallic molecules that consist of a ferrocene
moiety directly or indirectly attached to an indole core at any possible position of
substitution. A series of seven new ferrocene-indole molecules was synthesised,
designed and their cytotoxicity were tested against cancer cell lines. The study
concludes that ferrocene-indole with indole substituted at position 2 and 7 are more
active in cytotoxicity compared to the others in the series. The employed synthesis
method was a resemblance of Steglich Esterification, with EDC·HCl acted as
coupling agent and DMAP as catalyst. A precursor molecule,
ferrocenephenylenediamine was synthesised through EDC coupling. In addition, a
series of ferrocenephenyldiamide-indole was synthesised using the mentioned
precursor, with all six possible indoles substituted by the precursor. Characterisation
of the compounds were accomplished by Nuclear Magnetic Resonance (NMR),
Fourier-Transform Infrared Spectroscopy (FT-IR), CHN Elemental Analysis and
Mass Spectroscopy (MS). Meanwhile, MTS Assay was chosen as a biological
evaluation of the six ferrocene-indole hybrids. |
| format |
Thesis |
| author |
LIEW KEN MIN |
| spellingShingle |
LIEW KEN MIN SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS |
| author_facet |
LIEW KEN MIN |
| author_sort |
LIEW KEN MIN |
| title |
SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS |
| title_short |
SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS |
| title_full |
SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS |
| title_fullStr |
SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS |
| title_full_unstemmed |
SYNTHESIS, CHARACTERISATION, CYTOTOXIC ACTIVITY EVALUATION AND STRUCTURE-ACTIVIITY RELATIONSHIP STUDY OF NEW FERROCENE-INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS |
| title_sort |
synthesis, characterisation, cytotoxic activity evaluation and structure-activiity relationship study of new ferrocene-indole derivatives as potential anticancer agents |
| granting_institution |
UNIVERSITI MALAYSIA TERENGGANU |
| url |
http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/1/Abstract.pdf http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/16423/2/Synthesis%2c%20characterization%2c%20cytotoxic%20activity%20evaluation%20and%20structure-activity%20relationship%20study%20of%20new%20ferrocene-indole%20derivatives%20as%20potential%20anticancer%20agents.pdf |
| _version_ |
1747835833527828480 |