Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus

Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus

Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic...

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Main Author: Siti Nor Khadijah Addis
Format: Thesis
Language:English
Subjects:
QP 609 .P78 S5 2011
Siti Nor Khadijah Addis
Tesis The Australian National University 2011
Proteolytic enzymes
Online Access:http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/1653/1/QP%20609%20.P78%20S5%202011%20Abstract.pdf
http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/1653/2/QP%20609%20.P78%20S5%202011%20FullText.pdf
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id my-umt-ir.-1653
record_format uketd_dc
spelling my-umt-ir.-16532012-07-24T03:18:23Z Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus Siti Nor Khadijah Addis Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined. Australian national University 2011-11 Thesis en http://hdl.handle.net/123456789/1653 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/1653/1/QP%20609%20.P78%20S5%202011%20Abstract.pdf 94a892336a211a13da74ce655f3ce9a2 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/1653/2/QP%20609%20.P78%20S5%202011%20FullText.pdf cdb727df92110b08bfd5f20afc1270f6 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/1653/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 QP 609 .P78 S5 2011 Siti Nor Khadijah Addis Tesis The Australian National University 2011 Proteolytic enzymes
institution Universiti Malaysia Terengganu
collection UMT Repository System
language English
topic QP 609 .P78 S5 2011
Siti Nor Khadijah Addis
Tesis The Australian National University 2011
Proteolytic enzymes
spellingShingle QP 609 .P78 S5 2011
Siti Nor Khadijah Addis
Tesis The Australian National University 2011
Proteolytic enzymes
Siti Nor Khadijah Addis
Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
description Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined.
format Thesis
author Siti Nor Khadijah Addis
author_facet Siti Nor Khadijah Addis
author_sort Siti Nor Khadijah Addis
title Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_short Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_full Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_fullStr Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_full_unstemmed Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2a proteins of murray valley encephalitis virus
title_sort genetic and functional analysis of the proteolytic cleavage at the junction of the ns1 and ns2a proteins of murray valley encephalitis virus
granting_institution Australian national University
url http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/1653/1/QP%20609%20.P78%20S5%202011%20Abstract.pdf
http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/1653/2/QP%20609%20.P78%20S5%202011%20FullText.pdf
_version_ 1747835779133997056

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