The role of interleukin-8 in inflammatory responses of fish

Interleukin-8, a novel chemotactic cytokine, has been shown to play an important role in activation and recruitment of neutrophils, and thus acts as a traffic controller. This study builds upon the breakthrough in cloning several fish cytokine genes including IL-8. The predicted rainbow trout Oncorh...

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主要作者: Nor Omaima Harun
格式: Thesis
語言:English
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在線閱讀:http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/2723/1/QR%20185.8%20.I56%20N6%202006%20Abstract.pdf
http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/2723/2/QR%20185.8%20.I56%20N6%202006%20FullText.pdf
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總結:Interleukin-8, a novel chemotactic cytokine, has been shown to play an important role in activation and recruitment of neutrophils, and thus acts as a traffic controller. This study builds upon the breakthrough in cloning several fish cytokine genes including IL-8. The predicted rainbow trout Oncorhynchus mykiss mature interleukin-8 peptide has been produced as a recombinant protein in E. coli; interleukin-8 (riL-8a) and a mutated form lacking a receptor binding motif (riL-8b) were studied initially in vitro and in vivo.