Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities

Five species from Gracilariaceae, one Ulvaceae and one Scytosiphonaceae, two polysaccharides from Gracilaria spp. and three cholesterol derivatives were screened for their cytotoxicity (MTT assay method), antioxidant (DPPH free radical scavenging assay, xanthine oxidase inhibitory assay and total ph...

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Main Author:	Desy Fitrya, Syamsumir
Format:	Thesis
Language:	English
Subjects:	QK 569 .R4 D4 2008 Desy Fitrya Syamsumir Red algae
Online Access:	http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/1/QK%20569%20.R4%20D4%202008%20Abstract.pdf http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/2/QK%20569%20.R4%20D4%202008.pdf
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spelling	my-umt-ir.-6682016-03-10T09:08:24Z Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities Desy Fitrya, Syamsumir Five species from Gracilariaceae, one Ulvaceae and one Scytosiphonaceae, two polysaccharides from Gracilaria spp. and three cholesterol derivatives were screened for their cytotoxicity (MTT assay method), antioxidant (DPPH free radical scavenging assay, xanthine oxidase inhibitory assay and total phenolic content assay), antibacterial (disc diffusion method) and acetylcholinesterase inhibitory assay (TLC bioautographic method). Three species of Gracilariaceae were selected for further isolation due to the high quantity sample available and preliminary screening of biological activites on crude extracts. Three compounds were successfully isolated in this study, namely cholest-5-en-3-ol isolated from Gracilaria manilaensis, Gracilaria sp. and G. changii; hexadecanoic acid from G. manilaensis and G. changii\ and 1-(4'methoxyphenyl)-3-(2",4",6"-trihydroxyphenyl-3-hydroxypropanone from Gracilaria sp. The structures of these compounds were determined based on spectral data analysis and comparison with literature review. Fakulti Sains dan Teknologi 2008-12 Thesis en http://hdl.handle.net/123456789/668 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/1/QK%20569%20.R4%20D4%202008%20Abstract.pdf 53356a0e7d8432ba9aecdc245ce8fbcc http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/2/QK%20569%20.R4%20D4%202008.pdf 894558ad52daf4b4d4800aa92e01af6b http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/4/QK%20569%20.R4%20D4%202008%20Abstract.pdf.txt 699657ee9ce68fb0651faba3e26acc4d http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/5/QK%20569%20.R4%20D4%202008.pdf.txt c308acb0538c5d754fcec932d0de20de QK 569 .R4 D4 2008 Desy Fitrya Syamsumir Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities Red algae
institution	Universiti Malaysia Terengganu
collection	UMT Repository System
language	English
topic	QK 569 .R4 D4 2008 Desy Fitrya Syamsumir QK 569 .R4 D4 2008 Red algae
spellingShingle	QK 569 .R4 D4 2008 Desy Fitrya Syamsumir QK 569 .R4 D4 2008 Red algae Desy Fitrya, Syamsumir Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities
description	Five species from Gracilariaceae, one Ulvaceae and one Scytosiphonaceae, two polysaccharides from Gracilaria spp. and three cholesterol derivatives were screened for their cytotoxicity (MTT assay method), antioxidant (DPPH free radical scavenging assay, xanthine oxidase inhibitory assay and total phenolic content assay), antibacterial (disc diffusion method) and acetylcholinesterase inhibitory assay (TLC bioautographic method). Three species of Gracilariaceae were selected for further isolation due to the high quantity sample available and preliminary screening of biological activites on crude extracts. Three compounds were successfully isolated in this study, namely cholest-5-en-3-ol isolated from Gracilaria manilaensis, Gracilaria sp. and G. changii; hexadecanoic acid from G. manilaensis and G. changii\ and 1-(4'methoxyphenyl)-3-(2",4",6"-trihydroxyphenyl-3-hydroxypropanone from Gracilaria sp. The structures of these compounds were determined based on spectral data analysis and comparison with literature review.
format	Thesis
author	Desy Fitrya, Syamsumir
author_facet	Desy Fitrya, Syamsumir
author_sort	Desy Fitrya, Syamsumir
title	Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities
title_short	Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities
title_full	Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities
title_fullStr	Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities
title_full_unstemmed	Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities
title_sort	isolation and determination of chemical compounds from red algae, gracilaria manilaensis gracilaria sp. and g. changii and their bioactivities
granting_institution	Fakulti Sains dan Teknologi
url	http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/1/QK%20569%20.R4%20D4%202008%20Abstract.pdf http://umt-ir.umt.edu.my:8080/jspui/bitstream/123456789/668/2/QK%20569%20.R4%20D4%202008.pdf
_version_	1747835870457626624

Isolation and determination of chemical compounds from red algae, Gracilaria manilaensis gracilaria sp. and G. changii and their bioactivities

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