Integrated optical Mach-Zehnder interferometer for biosensor application

Dengue is an emerging global health problem affecting over half the world’s population. With the rapid pace of population growth and climate change, the population at risk of dengue has reached the figure of 2.5-3.0 billions, approximately 40% of the world’s population. Malaysia, a dengue hyperendem...

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Format:	Thesis
Language:	English
Subjects:	Interferometers Integrated optics Biosensors Point-of-care testing Dengue Dengue Biosensor
Online Access:	http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/1/Page%201-24.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/2/Full%20text.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/4/Khor%20Kang%20Nan.pdf
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id	my-unimap-77056
record_format	uketd_dc
spelling	my-unimap-770562022-11-17T01:35:39Z Integrated optical Mach-Zehnder interferometer for biosensor application Mukhzeer, Mohamad Shahimin, Dr. Dengue is an emerging global health problem affecting over half the world’s population. With the rapid pace of population growth and climate change, the population at risk of dengue has reached the figure of 2.5-3.0 billions, approximately 40% of the world’s population. Malaysia, a dengue hyperendemic country located near the equator, is one of the most affected countries by dengue in Western-Pacific region. The national target for the incidence rate of DF/DHF cases, 50 cases per 100,000 populations, has long been exceeded since 2005 until now. Rapid diagnostic test is in great demand ever since, however the current RDT is not sufficient as an effective passive surveillance system due to the high cost and lack of accuracy. Hence, this study aimed to develop a dengue RDT that is not only have the characteristics of point-ofcare (POC) diagnostic but also suits the criteria needed to achieve a large scale disease surveillance in most developing countries where resources are limited. Label-free optical biosensor had been proposed to realized an ideal surveillance RDT. The design of integrated optic Mach-Zehnder Interferometer (IO-MZI) biosensor had been carried out based on the simulation and fabrication method. Simulation of IO-MZI was carried out by using three-dimensional finite difference beam propagation method with the aim of sensitivity and detection limit optimization. OptiBPM software is selected because it is user-friendly and it allows three-dimensional simulation which is needed in this research. Universiti Malaysia Perlis (UniMAP) Thesis en http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77056 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/3/license.txt 8a4605be74aa9ea9d79846c1fba20a33 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/1/Page%201-24.pdf fb8c67200a92c771ca22bc83b08acec9 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/2/Full%20text.pdf b6f1c322d6a49e7e6b5fa12da1bd88a8 http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/4/Khor%20Kang%20Nan.pdf b06159d09046c514177462a0a318407c Universiti Malaysia Perlis (UniMAP) Interferometers Integrated optics Biosensors Point-of-care testing Dengue Dengue Biosensor School of Microelectronic Engineering
institution	Universiti Malaysia Perlis
collection	UniMAP Institutional Repository
language	English
advisor	Mukhzeer, Mohamad Shahimin, Dr.
topic	Interferometers Integrated optics Biosensors Point-of-care testing Dengue Dengue Biosensor
spellingShingle	Interferometers Integrated optics Biosensors Point-of-care testing Dengue Dengue Biosensor Integrated optical Mach-Zehnder interferometer for biosensor application
description	Dengue is an emerging global health problem affecting over half the world’s population. With the rapid pace of population growth and climate change, the population at risk of dengue has reached the figure of 2.5-3.0 billions, approximately 40% of the world’s population. Malaysia, a dengue hyperendemic country located near the equator, is one of the most affected countries by dengue in Western-Pacific region. The national target for the incidence rate of DF/DHF cases, 50 cases per 100,000 populations, has long been exceeded since 2005 until now. Rapid diagnostic test is in great demand ever since, however the current RDT is not sufficient as an effective passive surveillance system due to the high cost and lack of accuracy. Hence, this study aimed to develop a dengue RDT that is not only have the characteristics of point-ofcare (POC) diagnostic but also suits the criteria needed to achieve a large scale disease surveillance in most developing countries where resources are limited. Label-free optical biosensor had been proposed to realized an ideal surveillance RDT. The design of integrated optic Mach-Zehnder Interferometer (IO-MZI) biosensor had been carried out based on the simulation and fabrication method. Simulation of IO-MZI was carried out by using three-dimensional finite difference beam propagation method with the aim of sensitivity and detection limit optimization. OptiBPM software is selected because it is user-friendly and it allows three-dimensional simulation which is needed in this research.
format	Thesis
title	Integrated optical Mach-Zehnder interferometer for biosensor application
title_short	Integrated optical Mach-Zehnder interferometer for biosensor application
title_full	Integrated optical Mach-Zehnder interferometer for biosensor application
title_fullStr	Integrated optical Mach-Zehnder interferometer for biosensor application
title_full_unstemmed	Integrated optical Mach-Zehnder interferometer for biosensor application
title_sort	integrated optical mach-zehnder interferometer for biosensor application
granting_institution	Universiti Malaysia Perlis (UniMAP)
granting_department	School of Microelectronic Engineering
url	http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/1/Page%201-24.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/2/Full%20text.pdf http://dspace.unimap.edu.my:80/xmlui/bitstream/123456789/77056/4/Khor%20Kang%20Nan.pdf
_version_	1776104229897764864

Integrated optical Mach-Zehnder interferometer for biosensor application

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