Apoptosis-induced chromosome break in the AF9 gene

Chromosomal translocations are commonly associated with leukemia. Although the results of translocation are shown to be leukaemogenic, the initial event leading to the translocation remains mainly unknown. However, it is know that the initial step of translocation is the chromosome break event. Th...

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Main Author:	Cynthia Patricia, anak Nicholas
Format:	Thesis
Language:	English
Published:	2008
Subjects:	RB Pathology
Online Access:	http://ir.unimas.my/id/eprint/14116/1/Cynthia%20Patricia%20anak%20Nicholas%20ft.pdf
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id	my-unimas-ir.14116
record_format	uketd_dc
spelling	my-unimas-ir.141162023-05-10T02:50:56Z Apoptosis-induced chromosome break in the AF9 gene 2008 Cynthia Patricia, anak Nicholas RB Pathology Chromosomal translocations are commonly associated with leukemia. Although the results of translocation are shown to be leukaemogenic, the initial event leading to the translocation remains mainly unknown. However, it is know that the initial step of translocation is the chromosome break event. There are evidences that the apoptotic nuclease may play a role in chromosomal translocation as they are known to cleave the chromosome. Erroneous repair of these chromosomal breaks by DNA repair mechanisms may mediate chromosomal translocations. One of the genes frequently involved in chromosomal translocations in acute leukaemia is the AF9 gene. The AF9 gene is only one of the fusion partners of the MLL gene, thus the same hypothesis can be tested on other MLL fusion partner genes. It is possible that apoptosis may also play a role during chromosomal breakage in other MLL fusion partner genes too. Please get the password from Digital Collection Development Unit, ext : 3932 / 3914 2008 Thesis http://ir.unimas.my/id/eprint/14116/ http://ir.unimas.my/id/eprint/14116/1/Cynthia%20Patricia%20anak%20Nicholas%20ft.pdf text en validuser masters Universiti Malaysia Sarawak, (UNIMAS) Faculty of Medicine and Health Science
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	RB Pathology
spellingShingle	RB Pathology Cynthia Patricia, anak Nicholas Apoptosis-induced chromosome break in the AF9 gene
description	Chromosomal translocations are commonly associated with leukemia. Although the results of translocation are shown to be leukaemogenic, the initial event leading to the translocation remains mainly unknown. However, it is know that the initial step of translocation is the chromosome break event. There are evidences that the apoptotic nuclease may play a role in chromosomal translocation as they are known to cleave the chromosome. Erroneous repair of these chromosomal breaks by DNA repair mechanisms may mediate chromosomal translocations. One of the genes frequently involved in chromosomal translocations in acute leukaemia is the AF9 gene. The AF9 gene is only one of the fusion partners of the MLL gene, thus the same hypothesis can be tested on other MLL fusion partner genes. It is possible that apoptosis may also play a role during chromosomal breakage in other MLL fusion partner genes too.
format	Thesis
qualification_level	Master's degree
author	Cynthia Patricia, anak Nicholas
author_facet	Cynthia Patricia, anak Nicholas
author_sort	Cynthia Patricia, anak Nicholas
title	Apoptosis-induced chromosome break in the AF9 gene
title_short	Apoptosis-induced chromosome break in the AF9 gene
title_full	Apoptosis-induced chromosome break in the AF9 gene
title_fullStr	Apoptosis-induced chromosome break in the AF9 gene
title_full_unstemmed	Apoptosis-induced chromosome break in the AF9 gene
title_sort	apoptosis-induced chromosome break in the af9 gene
granting_institution	Universiti Malaysia Sarawak, (UNIMAS)
granting_department	Faculty of Medicine and Health Science
publishDate	2008
url	http://ir.unimas.my/id/eprint/14116/1/Cynthia%20Patricia%20anak%20Nicholas%20ft.pdf
_version_	1783728145996709888

Apoptosis-induced chromosome break in the AF9 gene

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