Synthesis of Kojic Acid Derivatives and their Applications
The development of potential value-added product derived from agriculture waste has become an attractive study among researchers. In this research, kojic acid 1 was successfully obtained via fermentation of sago waste as support-substrates, followed by series of chemical modification destined for...
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| Language: | English |
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2017
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| Online Access: | http://ir.unimas.my/id/eprint/20971/1/Carolynne.pdf |
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my-unimas-ir.209712023-07-27T08:13:28Z Synthesis of Kojic Acid Derivatives and their Applications 2017 Sie, Carolynne Zie Wei Q Science (General) QD Chemistry The development of potential value-added product derived from agriculture waste has become an attractive study among researchers. In this research, kojic acid 1 was successfully obtained via fermentation of sago waste as support-substrates, followed by series of chemical modification destined for biological and electrical applications. For biological application, a series of novel kojic acid-chalcone derivatives 40a-c has been successfully synthesized from the reaction of 1 prepared from sago waste with carboxyl chalcone 39a-c via Steglich esterification. Carboxyl chalcone 39a-c, which was prior prepared via Claisen Schmidt Condensation, showed active inhibition against Staphylococcus aureus with 39c gave the best inhibition of 8 mm. The incorporation of 1 into 39a-c, 40a-c gave a reverse antibacterial trend where 40a exhibited excellent zone of inhibition (8 mm) compared to ampicillin (11 mm). Novel kojic acid–azobenzene ester derivatives 49a-e bearing different vinyl chain lengths were also successfully synthesized via kojyl chloride 51 with azobenzene molecules. unimas 2017 Thesis http://ir.unimas.my/id/eprint/20971/ http://ir.unimas.my/id/eprint/20971/1/Carolynne.pdf text en validuser phd doctoral UNIMAS |
| institution |
Universiti Malaysia Sarawak |
| collection |
UNIMAS Institutional Repository |
| language |
English |
| topic |
Q Science (General) QD Chemistry |
| spellingShingle |
Q Science (General) QD Chemistry Sie, Carolynne Zie Wei Synthesis of Kojic Acid Derivatives and their Applications |
| description |
The development of potential value-added product derived from agriculture waste has become an attractive study among researchers. In this research, kojic acid 1 was successfully obtained via fermentation of sago waste as support-substrates, followed by series of chemical
modification destined for biological and electrical applications. For biological application, a series of novel kojic acid-chalcone derivatives 40a-c has been successfully synthesized from the reaction of 1 prepared from sago waste with carboxyl chalcone 39a-c via Steglich esterification. Carboxyl chalcone 39a-c, which was prior prepared via Claisen Schmidt Condensation, showed active inhibition against Staphylococcus aureus with 39c gave the best
inhibition of 8 mm. The incorporation of 1 into 39a-c, 40a-c gave a reverse antibacterial trend where 40a exhibited excellent zone of inhibition (8 mm) compared to ampicillin (11 mm). Novel kojic acid–azobenzene ester derivatives 49a-e bearing different vinyl chain lengths
were also successfully synthesized via kojyl chloride 51 with azobenzene molecules. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Sie, Carolynne Zie Wei |
| author_facet |
Sie, Carolynne Zie Wei |
| author_sort |
Sie, Carolynne Zie Wei |
| title |
Synthesis of Kojic Acid Derivatives and their Applications |
| title_short |
Synthesis of Kojic Acid Derivatives and their Applications |
| title_full |
Synthesis of Kojic Acid Derivatives and their Applications |
| title_fullStr |
Synthesis of Kojic Acid Derivatives and their Applications |
| title_full_unstemmed |
Synthesis of Kojic Acid Derivatives and their Applications |
| title_sort |
synthesis of kojic acid derivatives and their applications |
| granting_institution |
UNIMAS |
| publishDate |
2017 |
| url |
http://ir.unimas.my/id/eprint/20971/1/Carolynne.pdf |
| _version_ |
1783728212201701376 |